Protein Folding in the CellThis volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists. |
Contents
| 1 | |
Chapter 2 Allostery and Protein Substrate Conformational Change during GroELGroESMediated Protein Folding | 45 |
Chapter 3 Type II Chaperonins Prefoldin and the TubulinSpecific Chaperones | 73 |
Chapter 4 Structure and Function of the Small Heat Shock ProteinαCrystallin Family of Molecular Chaperones | 105 |
Chapter 5 Structure Function and Mechanism of the Hsp90 Molecular Chaperone | 157 |
A Supramolecular Assembly Designed for Controlled Proteolysis | 187 |
Chapter 7 Hsp70 Proteins in Protein Translocation | 223 |
Chapter 8 Prolyl Isomerases | 243 |
Chapter 10 NGlycan Processing and Glycoprotein Folding | 303 |
Chapter 11 Functional Genomic Approaches to Understanding Molecular Chaperones and Stress Responses | 345 |
Molecular Insights and Functional Consequences | 391 |
Chapter 13 Clp ATPases and Their Role in Protein Unfolding and Degradation | 413 |
| 431 | |
SUBJECT INDEX | 481 |
Color Plate Section | 493 |
Chapter 9 Catalysis of Disulfide Bond Formation and Isomerization in Escherichia coli | 283 |
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Common terms and phrases
20S proteasome Acad actin amino acids apical domains ATP binding ATPase ATPase domain Baumeister Biochem Biochemistry Bukau calnexin calreticulin catalyzed Cell Biol cellular cerevisiae chaperone activity chaperonin Chem Clp ATPases ClpA co-chaperones cofactors coli complex conformation cycle cyclophilin cytosolic degradation denatured dimer disulfide bonds DnaJ DnaK DsbA DsbB DsbC EMBOJ endoplasmic reticulum enzyme eukaryotic FEBS Lett function genes genetic glycoproteins glycosylation GroEL GroES heat shock homologs Horwich hydrolysis hydrophobic interaction isomerization Lindquist mechanism membrane misfolded mitochondrial molecular chaperones molecules motif mtHsp70 mutant N-terminal native Natl nucleotide oligomer oligomeric oligosaccharides oxidative pathway peptide bonds periplasm polypeptide prefoldin preprotein Proc proline prolyl isomerase protease proteasome protein folding PSI+ reaction receptor refolding reglucosylation residues RNase role Schmid sequence sHsps specific substrate substrate-binding subunits target protein teins tion trans translocation tubulin unfolded proteins UPR targets vitro vivo yeast