Cooperative Phenomena in BiologyGeorge Karreman Cooperative Phenomena in Biology deals with cooperation in biology and covers topics such as cooperative specific adsorption; the kinetics of oxygen binding to hemoglobin; allosteric control of cooperative adsorption and conformation changes; and cooperativity in biological surfaces responding to topical treatment. The use of Monte Carlo methods to investigate the behavior of cooperative Ising models is also described. This book is comprised of five chapters and opens with a discussion on the phenomenon of cooperative specific adsorption and its importance for the understanding of fundamental biological phenomena. The derivation of the cooperative specific adsorption isotherm both stochastically and on the basis of statistical mechanics is explained. The next chapter reviews the theory of the allosteric control of cooperative adsorption and conformation changes and outlines a molecular model for physiological activities according to the association-induction hypothesis. The reader is also introduced to a kinetic equation for hemoglobin oxygenation based on the infinite chain; the use of bioelectrometric methods to study solute interactions with biocolloidal surfaces responding to topical treatment; and the use of Monte Carlo computations to determine the behavior of cooperative Ising models. This monograph is intended for biologists, physicists, chemists, and mathematicians. |
Contents
| 1 | |
A Molecular Model for Physiological Activities According to the AssociationInduction Hypothesis | 39 |
Theory | 71 |
Chapter 4 Bioelectrometric Characterization of Cooperativity in Biological Surfaces Responding to Topical Treatment | 93 |
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Common terms and phrases
acid adjuvants adsorbed adsorption adsorption isotherm algebraic anionic association-induction hypothesis autocooperative average benzalkonium chloride benzene binding sites bioelectrometric Boltzmann factor buffer calculated carbachol cardinal adsorbent cationic chain Chem classical Monte Carlo colloid concentration configurations constant cooperative adsorption cooperative specific adsorption cornea corneal surface DEAE-dextran desorption determined dilution dissociation drug effects electrometric electron epidermal surface epidermis equation equilibrium experimental arrangement Figure fixed charge density frog skin function Gordon groups Gulati hemoglobin hexachlorophene human finger epidermis hydrophobic increase inductive Ising model Ising systems Karreman kinetics Ling living cells miotic molecules Monte Carlo method nearest neighbor observed obtained occurs ouabain oxygen parameters Pharm Phys plot polymer postulated potassium potential procaine properties protein rabbit random number sartorius muscle shown in Fig simulation sodium sorption statistical mechanics temperature theory tion titration titration curves transition probabilities uptake V. F. Smolen values vivo