Inflammatory Bowel Disease - Pathophysiology as Basis of TreatmentJ. Schölmerich Inflammatory bowel diseases are still a challenging problem in today's gastroenterology. Although their aetiology is still not understood, steady progress has been made recently in the understanding of their pathogenesis, due to the application of innovative molecular and cellular biological methods. Knowledge of the immunology of the gut and the basic mechanisms of inflammatory reactions, especially pro and anti-inflammatory mediators, the characterization of inflammatory cell types and their functions and molecules mediating cell interactions. This book closes the gap between new findings in pathophysiology and treatment in order to better understand our current therapeutic concepts and to develop new strategies for the future. It comprises the proceedings of the 67th Falk Symposium, held in Regensburg, June 1992, and contains sections on aetiology, pathophysiology, extra-intestinal mainfestations, diagnosis and treatment. It is essential reading for all clinicians treating IBD. |
Contents
Animal models | 3 |
The role of psychosocial factors | 19 |
Consequences of aetiological hypotheses for the treatment | 30 |
Copyright | |
39 other sections not shown
Common terms and phrases
5-aminosalicylic acid absorption active Crohn's disease acute ANCA anti-inflammatory antibodies antigen associated bacterial bile acid blood budesonide chronic Clin clinical colectomy colitis and Crohn's colon complications controlled trial corticosteroids Crohn's disease cyclosporin cytokines diarrhoea diet disease activity disease and ulcerative distal dose drug effect endoscopic enema factor faecal fistulae function Gastroenterology gastrointestinal genetic glutamine haemosorption human hydrocortisone ileal ileum immune Immunol increased indications induced inflammation inflammatory bowel disease inhibition interleukin lamina propria lesions leukotriene levels lymphocytes macrophages mediators mesalazine metabolism monocytes mucosa neutrophils ng/ml normal NSAIDs nutrition oral pathogenesis patients with Crohn's patients with IBD patients with ulcerative perianal plasma prednisolone primary sclerosing cholangitis production protein receptor rectal recurrence relapse remission resection response role Scand J Gastroenterol serum small bowel small intestine soluble specific steroids sulphasalazine surgery surgical symptoms synthesis systemic therapeutic therapy tissue treatment ulcerative colitis