Recombinant DNA

Front Cover
Macmillan, Feb 15, 1992 - Medical - 626 pages
This updated and revised second edition acts as an introduction to the conceps and techniques of recombinant DNA research and their results. The book features 14 new chapters and 11 rewritten chapters and incorperates research published throughout 1991. The coverage of recombinant DNA centres largely on key experiments, with sections focusing on new developments in cloning, mutagenisis, and genetic engineering, plus the contribution of recombinant DNA technology to our understanding of gene function, biological processes and human genetics.
 

Contents

Replacement
33
Phage DNA Can Insert into a Specific Site
49
METHODS OF CREATING
63
THE ISOLATION OF CLONED GENES
99
THE COMPLEXITY OF THE GENOME
135
TDNA Has Been Modified to Act as a Gene
313
ONCOGENES AND ANTIONCOGENES
335
ProtoOncogenes Encode Components
389
RECOMBINANT DNA AND EVOLUTION
433
The tat Gene Regulates Synthesis of HIV
489
MAPPING AND CLONING HUMAN
549
STUDYING WHOLE GENOMES
583
Copyright

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About the author (1992)

James Dewey Watson James D. Watson was born on April 6, 1928. Watson was an extremely industrious student and entered the University of Chicago when he was only 15. He received his Bachelor of Science degree in Zoology four years later, and went on to earn a Ph.D. in the same subject at Indiana University. He was performing research at the University of Copenhagen in Denmark, when he first learned of the biomolecular research at the Cavendish Laboratory of Cambridge University in England. Watson joined Francis Crick in this work in 1951. At the age of 25, he and colleague Crick discovered the structure of DNA, the double helix. Watson went on to become a Senior Research Fellow in Biology at the California Institute of Technology, before returning to Cambridge in 1955. The following year he moved to Harvard University, where he became Professor of Biology, a post he held until 1976. Watson and Crick won the 1962 Nobel Laureate in Medicine for their discoveries concerning the molecular structure of nuclear acids and its significance for information transfer in living material. In 1968, Watson published his account of the DNA discovery, "The Double Helix." The book became an international best-seller. Watson became the Director and later President of the Cold Spring Harbor Laboratory. In 1988 he served as Director of the Human Genome Project at the National Institutes of Health, a massive project to decipher the entire genetic code of the human species. Watson has received many awards and medals for his work, along with the Nobel Prize, he has also received the Presidential Medal of Freedom.