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abdominal abscess active Aliment Pharmacol Ther anal anastomosis anastomosis Ann Surg associated biopsies carcinoma cells chronic Clin clinical colectomy coli Colon Rectum colonoscopy colorectal cancer complications Crohn's disease cyclosporine desmoid tumors diagnosis drugs duodenal dysplasia effect endoscopic evaluation factors familial adenomatous polyposis fistula follow-up function Gastroenterol Gastroenterology gastrointestinal gene genetic histological IBD patients ileal pouch ileal pouch-anal anastomosis ileoanal ileostomy ileum incidence increased Inflamm Bowel inflammatory bowel disease infliximab intestinal IPAA laparoscopic lesions liver long-term ment mesalazine mesenteric mucosa mutations nutrition operation outcome patients with Crohn's patients with familial patients with IBD patients with ulcerative pelvic performed perianal placebo polyps postoperative pouchitis present procedure proctocolectomy rectal recurrence remission reported resection restorative proctocolectomy risk small bowel steroids stoma strictures surgery surgical treatment surveillance symptoms syndrome tion tive toxic megacolon tract transplantation treated trial tumours ulcerative colitis