Selection in Natural Populations
In 1974, Richard Lewontin published The Genetic Basis of Evolutionary Change, focusing enormous attention on protein variation as both a model of underlying genetic variation and a level of selection itself. In the twenty years since, scientific research has been shifted by the power of molecular biological techniques to explore the nature of variation directly at the DNA and gene levels. The "protein chapter" is coming to a close. In this book, Jeff Mitton explains the questions that geneticists hoped to answer by studying protein variation. He reviews the extensive literature on protein variation, describes the successes and failures of the research program, and evaluates the results of a rich and controversial body of research. The laboratory and field studies using protein polymorphisms revealed dynamic interactions among genotypes, fitness differentials, and fluctuating environmental conditions, and inadvertently wedded the fields of physiological ecology and population biology. Mitton's book is a useful analysis for all scientists interested in the genetic structure and evolution of populations.
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Natural Selection Fitness Determination and Molecular Variation
Classes of Abundant Genetic Variation
Environmental Heterogeneity and Enzyme Polymorphism
The Impact of a Single Gene
Patterns of Variation Among Loci
Female Choice and Male Fitness
3000 Drosophila allelic frequencies allozyme allozyme heterozygosity amino acid animals Anolis approximately associated average heterozygosity Avise axis Ayala biologists blue mussel chapter chromosomes Colias common components of fitness correlated dehydrogenase developmental stability differences differentiation eggs electrophoretic environmental heterogeneity environments enzyme kinetics enzyme loci equilibrium erozygosity estimated evolution evolutionary favored fecundity female choice figure fish fitness potential fluctuating asymmetry Fundulus gene flow genetic distance genetic variation geneticists genome genus geographic range growth rate Hamrick hemoglobin heterozy heterozygous higher homozygotes homozygous increased with heterozygosity individual heterozygosity killifish kinetic levels of genetic linkage disequilibrium markers measured melanogaster metabolic molecular morphological mtDNA multilocus natural populations natural selection Nevo offspring overdominance oxygen consumption Peromyscus phenotypes physiological pine plants polymorphic loci polymorphisms predictions produced protein protein heterozygosity protein polymorphisms random relationship respiration revealed salinity sample segregating sexual selection studies substrate temperature tion truncation selection vari variability variance viability zygotic
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Page 213 - Jeffreys, AJ, Royle, NJ, Wilson, V., and Wong, Z. (1988) Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA.
Page 225 - Rogers, S., Wells, R. and Rechsteiner, M. (1986) Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis.
Page 203 - Brown, JL 1997. A theory of mate choice based on heterozygosity. Behav. Ecol.
Page 206 - Diamond, SA, MC Newman, M. Mulvey, PM Dixon and D. Martinson, 1989. Allozyme genotype and time to death of mosquitofish, Gambusia affinis (Baird and Girard), during acute exposure to inorganic mercury. Environ. Toxicol. Chem.
Page 213 - minisatellite" regions in human DNA. Nature 314:67-73. Jeffreys, AJ, V. Wilson, and SL Thein. 1985b. Individual-specific "fingerprints
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