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5-aminosalicylic acid abdominal abnormalities abscess acute anal anastomosis ankylosing spondylitis antigens arthritis associated azathioprine barium biopsies cancer carcinoma cells chronic Clin clinical colectomy colitis and Crohn's colon colonoscopy complications controlled trial corticosteroids Crohn's colitis Crohn's disease diagnosis diarrhea diet dilatation disease activity disease and ulcerative distal dosage dose drug dysplasia endoscopic enemas epithelial evaluation factors fistulas Gastroenterol Gastroenterology genetic histologic hydrocortisone IBD patients ileal ileoanal ileostomy ileum immunosuppressive improved increased inflammation inflammatory bowel disease intestinal intravenous involvement Lancet lesions manifestations methotrexate metronidazole mucosa normal obstruction occur oral parenteral nutrition patients with Crohn's patients with ulcerative perianal physician placebo pouch procedure prednisolone prednisone present proctitis prognosis rectal rectum recurrence relapse remission reported resection response risk serum side effects sigmoidoscopic small bowel steroids stool strictures sulfasalazine Surg surgery surgical symptoms therapeutic therapy tion tissue toxic megacolon treated Truelove ulcerative colitis usually