IBD at the End of Its First CenturyG. Rogler, F. Kullman, P. Rutgeerts, R.B. Sartor, J. Schölmerich Although the first description of patients with what we now call Crohn's disease or ulcerative colitis was published well before 1900, both disorders seem to be diseases of the twentieth century. At the very start of the twenty-first century, it therefore seems appropriate to look back and at the same time look forward and to assess what knowledge has been gained during the last 100 years and in what direction research and thereby clinical practice will go in the future. This book, the proceedings of Falk Symposium No. 111 held in Freiburg, Germany, on June 19-20 1999, contains contributions from experienced senior scientists on the state of the art in pathophysiology, diagnosis and treatment, together with unpublished and new findings from young researchers. Basic scientists and clinicians are thereby involved in an exchange of information which will lead to new directions for future research and clinical management of inflammatory bowel diseases. |
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Page 35
... lymphocytes and an associated abnormal thymic structure33 . When bone marrow from syngeneic wild - type mice ( C57BL / 6 × CBA / J ) F , hybrids is transplanted into Tgɛ26 mice , very aggressive T lymphocytes develop due to a postulated ...
... lymphocytes and an associated abnormal thymic structure33 . When bone marrow from syngeneic wild - type mice ( C57BL / 6 × CBA / J ) F , hybrids is transplanted into Tgɛ26 mice , very aggressive T lymphocytes develop due to a postulated ...
Page 36
... lymphocytes developing in the abnormal thymic microenvironment of Tgɛ26 mice require the continuous presence of normal bacteria for the induction of colitis . Activated T lymphocytes are inca- pable of mediating colitis in the absence ...
... lymphocytes developing in the abnormal thymic microenvironment of Tgɛ26 mice require the continuous presence of normal bacteria for the induction of colitis . Activated T lymphocytes are inca- pable of mediating colitis in the absence ...
Page 111
... lymphocytes : defective mucosal lymphocyte apoptosis is associated with inflammation M. BOIRIVANT , M. MARINI and G. DI FELICE INTRODUCTION Cell death is an important event during immune response , allowing the removal of cells that are ...
... lymphocytes : defective mucosal lymphocyte apoptosis is associated with inflammation M. BOIRIVANT , M. MARINI and G. DI FELICE INTRODUCTION Cell death is an important event during immune response , allowing the removal of cells that are ...
Contents
Interleukin1ẞ gene polymorphisms as genetic markers | 12 |
Interactions between enteric bacteria and the immune | 30 |
future implications | 42 |
Copyright | |
26 other sections not shown
Common terms and phrases
acute allele antibody antigens apoptosis azathioprine bacteria CD4+ cell lines chromosome Clin Invest clinical colonic Crohn's disease crypt cyclosporin cytokine dendritic cells dose drug effects epithelial cells epithelium experimental expression Falk Symposium Figure function Gastroenterol Gastroenterology gastrointestinal genes genetic growth factor human intestinal IFN-y IKK activity immune response immune system Immunol immunological induced inflammation inflammatory bowel disease inhibition interactions interleukin interleukin-10 intestinal epithelial cells intestinal flora intravenous Lactobacillus lamina propria linkage luminal lymphocytes macrophages Madara JL mediated membrane mesalazine mice migration molecules mucosal mucosal immune murine myofibroblasts necrosis factor neutrophils normal oral tolerance pathogenesis pathway patients with Crohn's Peyer's patch phenotype Physiol Podolsky DK polymorphism pouch pouchitis probiotic proinflammatory protein rats receptor regulation remission role secretion small bowel steroids stimulation studies surgery susceptibility TGF-B thalidomide therapeutic therapy TNF-a transgenic treatment trefoil peptide trial ulcerative colitis vitro