Enteroimmunology: A Guide to Prevention and Treatment of Chronic Disease
Over half of the body's immune cells reside in the mucosal lining of the intestines. These cells, along with other mechanisms, protect the body from parasitic, bacterial, viral and fungal infection. The enteric immune system is highly competent at specifically targeting infectious agents, however, the immune system often also reacts to foods and other antigens presented to it. Enteroimmunology is an emerging field of medicine which elucidates how maladaptive reactions of the enteric immune system cause inflammatory disorders of multiple organ systems. These immune reactions, along with the production of cytokines and other immune modulators are responsible for much of the chronic disease burden in Western society. Enteroimmunology explains the metabolic and immune pathways, which when out of balance, give rise to chronic disease. This text provides the scientific rational for understanding enteroimmune disease, and provides a clinical guide for tertiary preventive treatment of these diseases. Enteroimmune diseases are not just bowel diseases such as irritable bowel syndrome and inflammatory bowel disease such as Crohn's disease, but also include both systemic and neurological diseases. Through explanation of the immune pathology underlying diseases local to immune reactions in the gut, it becomes clear how these same immune mechanisms cause systemic and neurological disease. Enteroimmunology explains the emerging understanding of the ecology of the gut and its relationship with diet, food and nutrition, and includes citations for nearly 2000 medical journal articles. It describes how IgG antergies to food, which are analogous to IgE allergies, cause a wide array of disease symptoms. This book explains leaky gut syndrome, small bowel overgrowth, dysbiosis, metabolic syndrome and how to achieve long-term effective resolution of these conditions through diet. The book gives examples of a variety of conditions and the pathological processes which underlie the causal mechanism of the diseases, and then provides a guide to the tertiary treatment for the condition. There are chapters on obesity and metabolic syndrome, fibromyalgia, autoimmune diseases, interstitial cystitis, sexual dysfunction, acne and other diseases. Neurological diseases discussed include autism, migraine, depression, multiple sclerosis and rage disorder. A chapter is dedicated to cancer prevention that explains the dietary factors responsible for the majority of human cancers, and which gives practical evidenced based advice for cancer prevention. A chapter is dedicated to explain the role of sleep disorders in enteroimmune disease. A chapter on mitochondrial health explains aging, and provides information of how individuals can maintain vibrant, healthy, mitochondria.
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