Fundamentals of InflammationCharles N. Serhan, Peter A. Ward, Derek W. Gilroy The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. The purpose of this book is to provide an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, postdoctoral Fellows, medical scientists, and researchers from other disciplines who wish to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation. |
Other editions - View all
Common terms and phrases
A2A receptor activation acute adaptive immune adenosine receptor adhesion molecules afferent airway allergic animal models anti-inflammatory antibodies antigen apoptosis arachidonic acid arthritis asthma autoimmune bacterial basophils binding blood bone cartilage CD4+ cellular chemokines chronic Clin clinical collagen complement cornea cytokines damage disease drugs effector effects eicosanoids endothelial cells endothelium enzymes eosinophils epithelial expression factor fibroblasts Figure function gene glomerular glomerulonephritis glomerulus granules human immune response Immunol increased induced infection infiltration inflammation inflammatory cells inflammatory response inhibition inhibitors injury innate immune integrins interactions intracellular kidney kinase lesions leukocyte leukotrienes ligands lipid lipoxins lung lupus lymphocytes macrophages mast cells mechanisms mediators membrane mice monocytes mouse mucosal murine nephritis neutrophils NSAIDs P-selectin pathogens pathways patients periodontal phagocytic phagocytosis plasma platelets production proinflammatory prostaglandin protein recruitment regulation release renal resolution resolvins rheumatoid role signaling specific stimulation stromal surface synovial T-cell target tion tissue tumor upregulation vascular vivo