The HLA Complex in Biology and Medicine: A Resource Book

Front Cover
Boydell & Brewer Ltd, Nov 26, 2010 - Medical - 608 pages

A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management.

This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

 

Contents

Immune SystemA Primer
3
Cytokines and T Cell Subsets
19
History of HLA
42
Genetic Structure and Functions of the Major Histocompatibility Complex
61
HLA Nomenclature
79
HLA Molecules of the Major Histocompatibility Complex
86
Immunogenetic Databases
119
Complement Genes in the Central Region of the MHC
135
Host Genetics of HIV1AIDS Infection
305
HLA and Drug Reactions
332
Insight into Human Health and Disease
350
Genetic Architecture of Mycobacterial Diseases
365
MHC and NonMHC Genes in Tuberculosis and Leprosy
386
Killer Cell Immunoglobulinlike Receptors in Health and Disease
406
Role of Nonclassical HLA Antigens in Pregnancy
424
Donors Selection Strategies for Hematopoietic Stem Cell Transplantation
449

Polymorphism Function and Evolution
159
HLA Typing Technologies
175
Computer Programs for the Development of SBT for HLA
188
The Genetics of Type 1 Diabetes
205
Genetic Determinants of Type 1 DiabetesImmune Response Genes
219
Genetics of Type 2 Diabetes
241
Immunogenetic Mechanisms of Celiac Disease
254
Immunogenetics of Rheumatoid Arthritis
276
HLA Architecture of HIV Disease Pathogenesis
292
Allorecognition
465
The Role of HLA Typing in Hematopoietic Stem Cell Transplantation
471
The Role of HLA Matching and Recipient Sensitization in Organ Allograft Outcome
491
Posttransplant Antibody Monitoring and Associated Mechanisms
510
The Influence of NK Cell Alloreactivity on Hematopoietic Stem Cell Transplantation
525
Minor Histocompatibility Antigens in Biology and Medicine
544
An Overview of Statistical Methods for Disease Gene Mapping Using Data on Related
566
Copyright

Common terms and phrases

abacavir activation alloreactivity amino acid analysis antibodies arthritis associated autoimmune blood bone marrow CD4+ Chapter chromosome class I molecules Clin clinical complement crossmatch cytokines cytotoxic differentiation disease DRB1 effect encoded epitopes exon expression factor frequency function genetic genome genotype graft GVHD haplotypes hematopoietic heterozygous HLA alleles HLA antibodies HLA antigens HLA class HLA matching HLA molecules HLA typing HLA-A HLA-B HLA-C HLA-DR HLA-E HLA-G human hypersensitivity immune response Immunogenetics Immunol Immunology individuals induced infection inhibitory insulin interaction KIR genes leprosy leukocyte ligand linkage loci locus lymphocytes major histocompatibility complex Marrow Transplant mediated MHC class mice minor H antigens mismatches molecular mutations natural killer cell NK cells nucleotide pathogens pathway patients peptide percent phenotype polymorphism population protein recipient region registries risk role sequence signaling SNPs specific studies susceptibility T-cell Tissue Antigens tuberculosis type 1 diabetes unrelated donor variants viral

Bibliographic information

TitleThe HLA Complex in Biology and Medicine: A Resource Book
AuthorNarinder K Mehra
EditorsNarinder K Mehra, Gurvinder Kaur, James McCluskey, Frank T. Christiansen
Editionillustrated
PublisherBoydell & Brewer Ltd, 2010
ISBN818448870X, 9788184488708
Length608 pages
Subjects › 

Medical / Immunology
Medical / Laboratory Medicine
Medical / Pathology
Medical / Physiology
  
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