The Nitro Group in Organic SynthesisThe most useful reactions of organonitro compounds in organic synthesis Compounds containing nitro groups are useful intermediates for the synthesis of natural products and other complex organic molecules. The Nitro Group in Organic Synthesis focuses on reactions that proceed under mild conditions, important functional groups that can be synthesized by conversion of nitro groups, and the stereoselectivity of reactions of nitro compounds. These issues are of great importance to practicing researchers in today's pharmaceutical, agrochemical, and fine chemical industries. The Nitro Group in Organic Synthesis also emphasizes environmentally-friendly methods for nitration, the importance of aliphatic nitro compounds, and modern preparation of nitro compounds. Other topics discussed include: * Henry reaction * Asymmetric Michael addition * Alkylation, acylation, halogenation, and related reactions of RNO2 * Substitution and elimination of NO2 and RNO2 The Nitro Group in Organic Synthesis is a useful resource for researchers and students in organic and medicinal chemistry. |
Contents
| 1 | |
| 3 | |
3The NitroAldol Henry Reaction | 30 |
4 Michael Addition | 70 |
5 Alkylation Acylation and Halogenation of Nitro Compounds | 126 |
6 Conversion of Nitro Compounds into Other Compounds | 159 |
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acetic acid active AIBN alcohols aldehydes alkenes alkyl allylic amines amino anion applied aromatic asymmetric Ballini base Bu3SnH carbon catalyst Chapter Chem Chemistry Chim chiral CO2Et CO2Me Commun converted corresponding coworkers cyclic cycloaddition denitration derivatives developed Diels-Alder reaction DMSO effective elimination esters ether example followed formed functionalized give Henry reaction heterocycles hydrogen important ketones method Michael addition natural Nef reaction nitration nitro compounds nitro group nitro-aldol nitroalkenes nitromethane NO2 NO2 NO2 Ph nucleophiles OH OH organic synthesis oxidation Perkin Trans Ph NO2 Ph Ph prepared presence proceeds provides pyrroles radical reaction reactive reagents recent reduction reported ring Scheme selectivity shown in Eq simple stereoselective strategy substitution Synlett Synth Tetrahedron Lett treatment various yield Zard