Water and Biological MacromoleculesWesthof Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging. Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists. |
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Page 228
Westhof. Table 7.1 Structural water - mediated bridges in nucleic acids HYDRATION AROUND PHOSPHATE GROUPS Cones of hydration ( B- and Z - DNA ) O1P ( i ) ˇ ˇ ˇ W ˇ ˇ ˇ O2P ( i + 1 ) bridges ... phosphate groups 5'-Phosphate-water-base ...
Westhof. Table 7.1 Structural water - mediated bridges in nucleic acids HYDRATION AROUND PHOSPHATE GROUPS Cones of hydration ( B- and Z - DNA ) O1P ( i ) ˇ ˇ ˇ W ˇ ˇ ˇ O2P ( i + 1 ) bridges ... phosphate groups 5'-Phosphate-water-base ...
Page 229
... Phosphate Groups Around each anionic phosphate oxygen , the motif most frequently seen , in nucleotides as well as in oligonucleotides , is the ' cone of hydra- tion ' built of three water molecules . This motif was predicted by Pull ...
... Phosphate Groups Around each anionic phosphate oxygen , the motif most frequently seen , in nucleotides as well as in oligonucleotides , is the ' cone of hydra- tion ' built of three water molecules . This motif was predicted by Pull ...
Page 257
... groups along the phosphate backbone and accessible polar base atoms are hydrated . Solvent molecules often formed complex networks consisting of loops or chains linking polar groups at different parts of the nucleotide . Monte Carlo ...
... groups along the phosphate backbone and accessible polar base atoms are hydrated . Solvent molecules often formed complex networks consisting of loops or chains linking polar groups at different parts of the nucleotide . Monte Carlo ...
Contents
Water structure | 3 |
Thermodynamic and dynamic properties of water | 45 |
Aqueous solutions of simple hydrophobic solutes | 55 |
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Acta Cryst analysis anionic aqueous atoms B-DNA B-form backbone base pairs Beveridge binding Biochemistry Biochim Biol Biomol Biophys Biopolymers calculations Cevc chain Chem Clementi complex conformation counterions crystal structure crystalline crystallographic d(CGCGAATTCGCG density distance dodecamer electron electrostatic Equation experimental Figure force field free energy function Gibbs energy Goodfellow H-bond helix hydration hydration forces hydration shell hydrogen bonds hydrophilic hydrophobic ice Ih interactions interfacial ions lipid bilayers lipid headgroups liquid macromolecules MD simulation membrane minor groove mJ/m˛ molecular dynamics Molecular dynamics simulation Monte Carlo neutron diffraction nucleic acids nucleotide orientation oxygen phase phosphate groups phosphatidylcholine phospholipid Phys polar polymer polysaccharides potential refinement region relaxation repulsive residues resolution Saenger side-chains solution solvation solvation Gibbs energy solvent solvent molecules solvent structure ẞ-sheet stability Struct studies surface temperature tion water bridges water molecules water structure Westhof X-ray Z-DNA