Water and Biological MacromoleculesWesthof Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging. Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists. |
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Page 166
... stability of a sequence remains necessarily tenuous . A fundamental approach to ' explaining ' stability is to develop a theor- etical model for the system which accurately accounts for the relevant observed data , and then examine the ...
... stability of a sequence remains necessarily tenuous . A fundamental approach to ' explaining ' stability is to develop a theor- etical model for the system which accurately accounts for the relevant observed data , and then examine the ...
Page 227
... stability of nucleic acid helices was suggested by Geiduschek and Gray ( 1956 ) . Later , base- stacking forces together with hydrogen bonding between complementary bases were held responsible for double - helical structures in solution ...
... stability of nucleic acid helices was suggested by Geiduschek and Gray ( 1956 ) . Later , base- stacking forces together with hydrogen bonding between complementary bases were held responsible for double - helical structures in solution ...
Page 416
... stability . This is because the DLVO theory only con- siders van der Waals - London attractions and electrostatic repulsions , as a function of distance , and does not account for the quantitatively usually exceedingly important ...
... stability . This is because the DLVO theory only con- siders van der Waals - London attractions and electrostatic repulsions , as a function of distance , and does not account for the quantitatively usually exceedingly important ...
Contents
Water structure | 3 |
Thermodynamic and dynamic properties of water | 45 |
Aqueous solutions of simple hydrophobic solutes | 55 |
Copyright | |
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Acta Cryst analysis anionic aqueous atoms B-DNA B-form backbone base pairs Beveridge binding Biochemistry Biochim Biol Biomol Biophys Biopolymers calculations Cevc chain Chem Clementi complex conformation counterions crystal structure crystalline crystallographic d(CGCGAATTCGCG density distance dodecamer electron electrostatic Equation experimental Figure force field free energy function Gibbs energy Goodfellow H-bond helix hydration hydration forces hydration shell hydrogen bonds hydrophilic hydrophobic ice Ih interactions interfacial ions lipid bilayers lipid headgroups liquid macromolecules MD simulation membrane minor groove mJ/m˛ molecular dynamics Molecular dynamics simulation Monte Carlo neutron diffraction nucleic acids nucleotide orientation oxygen phase phosphate groups phosphatidylcholine phospholipid Phys polar polymer polysaccharides potential refinement region relaxation repulsive residues resolution Saenger side-chains solution solvation solvation Gibbs energy solvent solvent molecules solvent structure ẞ-sheet stability Struct studies surface temperature tion water bridges water molecules water structure Westhof X-ray Z-DNA