In-Vitro Toxicity Testing: Applications to Safety EvaluationJohn M. Frazier This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses. |
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Contents
General Perspectives on In Vitro Toxicity Testing | 1 |
In Vitro Technology Trends and Issues | 13 |
Hepatotoxicity | 45 |
An Evaluation of In Vitro Models for Assessing Nephrotoxicity | 85 |
Neurotoxicity | 111 |
Cardiovascular Toxicity | 131 |
Ocular Irritation | 149 |
Cutaneous Irritancy | 191 |
Teratogenicity | 205 |
Carcinogenicity The Use of Animal Models and ShortTerm Predictive Tests | 221 |
Validation of In Vitro Toxicity Tests | 245 |
Industrial Applications for In Vitro Toxicity Evaluation A Tier Testing Strategy for Product Safety Assessment | 253 |
Regulatory Law and the Use of In Vitro Methods for the Assessment of Various Toxicities | 281 |
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Other editions - View all
In-Vitro Toxicity Testing: Applications to Safety Evaluation John M. Frazier No preview available - 1992 |
Common terms and phrases
A. M. Goldberg acid activity adult agents alternative animal testing battery biochemical Biol cancer carcinogens cell cultures cell line cell types cellular chemicals compounds concentrations corneal correlation culture system cytochrome P-450 cytotoxicity database differentiation Draize drug effects embryo endpoints enzyme epithelial cells evaluation explant cultures exposure eye irritation fibroblasts Food Chem function genotoxic Guguen-Guillouzo Guillouzo hepatitis hepatocytes hepatotoxicity human hepatocytes induced injury irritancy potential irritation testing keratinocytes kidney laboratory liver cells Mary Ann Liebert mechanisms mechanistic membrane metabolism metabolites molecular mouse MPP+ MPTP mutagenicity Mutat myocytes nephrotoxicity nephrotoxins neurons neurotoxic ocular irritation organ Pharmacol predictive primary cultures protein proximal tubule rabbit rat hepatocytes response rodent screening short-term tests slices specific studies substances techniques teratogenicity test materials test system tion toxi Toxicol tumor uptake validation vascular vitro assays vitro methods vitro model vitro systems vitro tests vitro toxicity testing Vitro Toxicology vivo xenobiotics
References to this book
In Vitro Methods in Pharmaceutical Research Jose V. Castell,Maria Jose Gmez-Lechn Limited preview - 1996 |