Neurodevelopment and Adult Psychopathology

Front Cover
Cambridge University Press, Sep 11, 1997 - Medical - 282 pages
In this important 1997 book on the role of neurodevelopmental factors in the pathogenesis of the major psychiatric disorders, the fields of developmental neurobiology, clinical psychiatry and behavioural neuroscience are reviewed by an international group of experts, including many of those responsible for the ideas that have come to dominate current thinking. The first section, 'The Developing Brain', reviews neurodevelopment from the molecular to the behavioural level. Section Two, 'Development and Psychopathology', covers clinical applications of the basic principles of developmental neurobiology. The third and final section, 'Integrative Models', presents approaches toward a synthesis of neurodevelopmental and clinical findings in psychiatric disorder. For students, scientists and clinicians in psychiatry, psychology, and neurodevelopment, this is an essential reference.

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Contents

Development of the cerebral cortex an overview
3
Development of the primate prefrontal cortex
12
The genetics of neurodevelopment and schizophrenia
31
Glutamate receptors and developmental anomaly in medial temporal lobe in schizophrenia
57
Magnetic resonance imaging studies of developing brain
63
³¹P magnetic resonance spectroscopy studies of developing brain
71
Position emission tomography studies of developing brain
93
Longterm effects of different early rearing experiences on social emotional and physiological development in nonhuman primates
104
Psychopathology and brain dysfunction structural imaging studies
178
Neuropathology neurodevelopment and schizophrenia
187
Neurodevelopmental models of affective disorders
199
Heterogeneity within obsessive compulsive disorder evidence for primary and neurodevelopmental subtypes
206
Schizophrenia a critique from the developmental psychopathology perspective
213
Integrative models
235
Schizophrenia as an emergent disorder of late brain maturation
237
Schizophrenia as a developmental disorder of neural network integrity the dysplastic net hypothesis
253

Development and psychopathology
117
From birth to onset a developmental perspective of schizophrenia in two national birth cohorts
119
Developmental aspects of schizophrenia
137
Sex differences in schizophrenia
155
Neurodevelopment and schizophrenia quo vadis?
267
Index
278
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