Assessment of the Risk of Hepatotoxicity with Kava Products

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WHO Regional Office Europe, 2007 - Medical - 82 pages
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There has been international concern over the association of kava products and serious hepatotoxicity. Regulatory action banning these products in Europe has been controversial. The objective of this report is to investigate the possibility of hepatotoxicity with kava. It contains a description of kava and provides safety information as well as information on regulatory issues, conclusions and recommendations by the Committee appointed to handle this enquiry.
 

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Page 36 - Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain.
Page 28 - Anticonvulsive action of (+/— )-kavain estimated from its properties on stimulated synaptosomes and Na+ channel receptor sites.
Page 43 - C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol 1992;215:265-9.
Page 37 - Walden J, von Wegerer J, Winter U, Berger M, Grunze H. Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Progress Neuropsychopharmacol Biol Psychiat 1997:21:697-706.

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World Health Organization

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