Assessment of the Risk of Hepatotoxicity with Kava Products
There has been international concern over the association of kava products and serious hepatotoxicity. Regulatory action banning these products in Europe has been controversial. The objective of this report is to investigate the possibility of hepatotoxicity with kava. It contains a description of kava and provides safety information as well as information on regulatory issues, conclusions and recommendations by the Committee appointed to handle this enquiry.
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acetonic acetonic and ethanolic acetonic extracts Adverse effects adverse events alcohol anxiolytics assessment associated with kava benzodiazepines BfArM causality Cholestatic hepatitis Clinical Trial database Denham Diclofenac dihydromethysticin dose double-blind Drug effects of kava efficacy EMEA Ernst Ethanol Ethanol Ethanol Ethanol ethanolic extracts evaluation extracts of kava Fiji German Gruenwald Health Health Canada hepatic events Hepatic failure Hepatic function Hepatic necrosis hepatotoxicity with kava herbal medicines hydrochlorothiazide kava extract kava lactones kava Piper methysticum kava preparations kava products kava root kava-containing products Kavain Laitan Lebot liver damage liver disease liver toxicity liver transplants Medical Journal Number of subjects organic extracts oxazepam patients Pharmacology pharmacovigilance Phytomedicine Phytopharm Phytotherapy Piper methysticum placebo plant Planta Medica potential Psychopharmacology pyrones rechallenge regulatory reports of hepatotoxicity Review rhizome risk Schmidt Singh YN Stickel Suva synthetic products Table therapy treatment of anxiety water extracts Yes Y N Yes Yes Yes
Page 36 - Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain.
Page 43 - C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol 1992;215:265-9.