Neural Development and Stem CellsMahendra S. Rao, Mohan C. Vemuri, Melissa Carpenter Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi). |
From inside the book
Results 1-5 of 25
Page v
... Cells will serve as a handy guide for a course on stem cell biology in the nervous system for the novice and expert alike. Mahendra S. Rao, MBBS , PhD CNS NSC Adult stem cell Quiesence Transdifferentiation Self renewal Death v Preface.
... Cells will serve as a handy guide for a course on stem cell biology in the nervous system for the novice and expert alike. Mahendra S. Rao, MBBS , PhD CNS NSC Adult stem cell Quiesence Transdifferentiation Self renewal Death v Preface.
Page vi
... Transdifferentiation Self renewal Death Differentiation NRP GRP Intermediate Precursors dedifferentiation Differentiated cells Neurons Astrocyte Oligodendrocytes Fig . 1. Multipotent stem cells ( NSC ) can undergo self - renewal , enter ...
... Transdifferentiation Self renewal Death Differentiation NRP GRP Intermediate Precursors dedifferentiation Differentiated cells Neurons Astrocyte Oligodendrocytes Fig . 1. Multipotent stem cells ( NSC ) can undergo self - renewal , enter ...
Page vii
... Transdifferentiation in the Nervous System 189 Ying Liu and Mahendra S. Rao ..................................................................... 249 12 Neural Progenitor Cells of the Adult Human Brain Steven A. Goldman ....
... Transdifferentiation in the Nervous System 189 Ying Liu and Mahendra S. Rao ..................................................................... 249 12 Neural Progenitor Cells of the Adult Human Brain Steven A. Goldman ....
Page 4
... transdifferentiation or dedifferen- tiation? Or could there be a small population of totipotent stem cells in the brain, per- haps even derivatives of migratory germ cells that did not reach the germinal ridges (45), that was ...
... transdifferentiation or dedifferen- tiation? Or could there be a small population of totipotent stem cells in the brain, per- haps even derivatives of migratory germ cells that did not reach the germinal ridges (45), that was ...
Page 247
You have reached your viewing limit for this book.
You have reached your viewing limit for this book.
Contents
1 | |
Cellular and Molecular Properties of Multipotent Neural Stem Cells | 49 |
Multipotent Stem Cells in the Embryonic Nervous System | 67 |
Rizwan S Akhtar and Kevin A Roth | 97 |
Neuronal Progenitor Cells of the Mammalian Neonatal | 123 |
Glial Restricted Precursors | 143 |
PNS Precursor Cells in Development and Cancer | 189 |
James E Schwob and Woochan Jang | 219 |
Transdifferentiation in the Nervous System | 249 |
Neural Progenitor Cells of the Adult Human Brain | 267 |
Embryonic Stem Cells and Neurogenesis | 299 |
Central Nervous System | 343 |
Neural Stem Cell Companies | 421 |
Patents and Stem Cells | 429 |
Index | 445 |
Retinal Stem Cells | 235 |
Other editions - View all
Neural Development and Stem Cells Scott Lipnick,Mohan C. Vemuri,Melissa Carpenter No preview available - 2010 |
Common terms and phrases
Acad activity adult brain adult human adult mammalian adult rat Alvarez-Buylla apoptosis astrocytes axons bHLH Biol Brain Res BrdU cell cycle cell death cell fate cell lines cell populations cell types cells derived clonal clones cortex cortical crest stem cells culture dentate gyrus developmental dorsal embryonic stem cells fetal forebrain function gene glial cells growth factor GRP cells hippocampus induced isolated lineage markers mice migration molecules mouse multipotent multipotential murine myelin Natl neonatal neural crest cells neural crest stem neural precursor cells neural progenitor neural progenitor cells neural stem cells neural tube Neurobiol neurogenesis neurogenic Neurosci neurospheres NSCs olfactory bulb oligodendrocytes pathway phenotype pluripotent pluripotent stem cells postnatal potential Proc progenitor cells proliferation promote proteins radial glia receptor regions regulation restricted retinal role self-renewal signaling specific spinal cord subventricular zone SVZa tion tissue transdifferentiation transplantation ventral ventricular zone vitro vivo