Biological Aspects of DiseaseAnimal models are critical to advancing the understanding of and intervention in human disease in almost all areas of the life sciences. This volume provides examples of how animal experimentation leads to data applicable to human disease. The ethics of animal use is explored, and details of the advantages of animal models over alternate systems are presented. The text guides the thought processes of students and scientists as they evaluate the potential use of animals in their own biomedical research. |
Contents
Transgenic Animal Models of Disease | 15 |
Of Mice | 39 |
Animal Models in Gene Therapy | 69 |
Animal Models for LeschNyhan Disease | 93 |
Animal Models of Human Central Nervous System | 145 |
Transgenic Animal Models in Hypertension | 165 |
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abnormalities Acad Sci USA acid activity adenosine AIDS Res Hum angiotensinogen animal models antibodies antigens basal basal ganglia behavior Biochem Biol blood pressure brain dopamine Brinster cause cells clinical clone defect deficiency depletion differentiation duct effects embryos enzyme epidermis experimental factors follicle function Ganten Gaucher disease gene therapy gene transfer genetic glucocerebrosidase HIV-1 infected HPRT human disease Hypertension immune response induced involved keratin keratinocytes kidney layers lentivirus lentiviruses lesions levels liver macaques macrophages marsupials metabolism molecular monkeys mouse models muscle mutations myelin Natl Acad Sci neurobehavioral neurons normal oncogenes ovary overexpression oviduct pathogenesis pathogenic patients Pharmacol phenotype plasma Proc Natl Acad produce promoter protein receptor recombinant region renin renin gene replication reproductive Res Hum Retroviruses role Science skin specific strains structure studies targeted tion tissue toxic transgenic mice transgenic models tumors uterus vaccines viral Virol virus vitro vivo