Mammalian GenomicsAnatoly Ruvinsky, Jennifer A. Marshall Graves Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion and lab animals. Topics covered include structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, evolution of DNA sequences, comparative chromosome mapping and painting, genome databases, gene prediction and the use of genomic information to understand inherited diseases. Contributors include leading researchers from Europe, USA, Australia and Japan. |
Contents
| 1 | |
| 23 | |
3 Mapping Genomes at the Molecular Level | 67 |
| 87 | |
5 The Transcriptome | 117 |
6 The Proteome | 153 |
Epigenetic Regulation of Gene Expression in Mammalian Species | 179 |
8 Regulation of Genome Activity and Genetic Networks in Mammals | 201 |
13 Evolution of the Mammalian Karyotype | 317 |
14 Comparative Gene Mapping Chromosome Painting and the Reconstruction of the Ancestral Mammalian Karyotype | 349 |
From Computational Analysis through to Integrated Systems | 393 |
16 Genetic Databases | 411 |
17 Gene Predictions and Annotations | 429 |
18 Genomic Research and Progress in Understanding Inherited Disorders in Humans and Other Mammals | 449 |
19 Pharmacogenomics | 477 |
20 Genome Scanning for Quantitative Trait Loci | 507 |
9 Inducing Alterations in the Mammalian Genome for Investigating the Functions of Genes | 221 |
Prokaryote and Eukaryote Perspectives | 263 |
11 Elements and Mechanisms of Genome Change | 279 |
12 DNA Sequence Evolution and Phylogenetic Footprinting | 301 |
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