Controversies in Neuro-oncologyT. Wiegel This volume brings together an interdisciplinary group of specialists to present and discuss the latest diagnostic and therapeutic concepts and current controversial issues in the management of primary and secondary brain tumors. In the first part, the latest technical developments in neuro-oncology are presented. These include the evaluation of positron-emission tomography for diagnosis, and neuronavigation and operative mapping for operation planning. Innovations in computer-assisted 3-D radiotherapy planning and in image fusioning of CT, MRT, SPECT and PET are also described. A large section of the book is devoted to the diagnosis and interdisciplinary treatment of glioblastoma, one of the most frequently occurring brain tumors. In-depth coverage is given to pathological differential diagnosis, operative standards and the results of radiotherapy. A detailed presentation of the current chemotherapeutic strategies as well as their evaluation within an interdisciplinary therapy concept is also provided. A special chapter focuses on the role of radiotherapy and neurosurgery in the treatment of craniopharyngioma. The final section features discussions on the therapeutic options for brain metastases. Individual indications for both whole-brain irradiation and radiosurgery are given and compared with neurosurgical intervention. New experimental chemotherapies are considered, and finally, the palliative use of chemotherapy is examined. In summary, this book provides an excellent survey of the state of the art in neuro-oncology. It is therefore recommended reading for all clinical neuropathologists, neurologists, neurosurgeons and radiation oncologists. |
Contents
Recent Advances of PET in the Diagnosis of Brain Tumors | 9 |
A Useful Tool for Preoperative Rolandic Fissure | 23 |
The Value of Iodine123AlphaMethylLTyrosine SinglePhoton | 37 |
Boron Neutron Capture Enhancement of Fast Neutron | 43 |
Commissioning of a MicroMultileaf Collimator | 51 |
Commissioning of a MicroMultileaf Collimator for Conformal | 64 |
Neuronavigation and Magnetic Source Imaging in Brain Tumors | 78 |
The Value of 3D Magnetic Resonance Imaging in the Planning | 88 |
Comparison of Coplanar and NonCoplanar Irradiation Techniques | 202 |
New Perspectives and Experimental Therapy | 214 |
IntraArterial Virus and Nonvirus VectorMediated Gene Transfer | 227 |
Focal Fractionated Conformal Stereotactic Boost following | 241 |
Radiation Tolerance and ReIrradiation of the | 253 |
Pathophysiological Mechanisms Leading to the Development of Late | 265 |
Reirradiation after Radiotherapy of Primary Brain Tumors | 276 |
Effects of HighDose Radiotherapy to Tumors of the Pituitary on | 284 |
Intraoperative Radiotherapy in Brain Tumors | 94 |
Craniopharyngeoma | 100 |
Craniopharyngeomas Results in Children and Adolescents | 114 |
Glioblastoma Clinical Treatment Strategies | 123 |
Current Approaches to Radiation Therapy for Malignant Gliomas | 139 |
Hyperfractionated Reirradiation for Malignant Glioma | 150 |
Outcome and Side Effects in Radiotherapy of Glioblastoma | 158 |
Conventionally Fractionated Radiotherapy of Glioblastoma | 166 |
Chemotherapy in Adult Malignant Glioma | 174 |
Influence of Progress | 192 |
Radiomyelopathy after Conventionally Fractionated | 293 |
DoseVolume Tolerance of the Brainstem after HighDose | 305 |
Debus J Heidelberg Hug E B Liebsch N J OFarrel D Finkelstein D | 315 |
An Overview | 327 |
Chemotherapy of Brain Metastases | 343 |
Chemotherapy followed by Radiotherapy | 349 |
Topotecan as a 21Day Continuous Infusion with Accelerated | 364 |
371 | |
Common terms and phrases
analysis anaplastic astrocytic BCNU beam blood-brain barrier brain metastases brain tumors brainstem carboplatin cerebral chiasm Clin Oncol clinical collimator compared Controversies in Neuro-Oncology cortical craniopharyngioma disease etoposide evaluation factors field follow-up fractions Front Radiat Ther functional glioblastoma multiforme grade high-dose high-grade gliomas Hinkelbein Hoell T eds hyperfractionation imaging increased Int J Radiat intracranial intraoperative intratumoral irradiation isocentre isodose lesions lung cancer malignant glioma median survival mMLC months myelopathy necrosis neurological neuronavigation Neurooncol Neurosurg Neurosurgery normal brain normal tissue oligoastrocytoma oligodendroglioma Oncol Biol Phys Oncology optic patients with recurrent phase II study postoperative preoperative primary prognosis Radiat Oncol Biol Radiat Ther Oncol radiation therapy Radiother reirradiation reported resection response side effects significant spinal cord stereotactic radiosurgery surgery surgical target volume techniques therapeutic topotecan total dose toxicity treatment planning trial tumor cells uptake vectors WBRT Wiegel