Mammalian Genomics

Front Cover
Anatoly Ruvinsky, Jennifer A. Marshall Graves
CABI, 2005 - Science - 600 pages
Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion and lab animals. Topics covered include structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, evolution of DNA sequences, comparative chromosome mapping and painting, genome databases, gene prediction and the use of genomic information to understand inherited diseases. Contributors include leading researchers from Europe, USA, Australia and Japan.
 

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Contents

2 Mapping Genomes at the Chromosome Level
23
3 Mapping Genomes at the Molecular Level
67
4 DNA Sequence of the Human and Other Mammalian Genomes
87
5 The Transcriptome
117
6 The Proteome
153
Epigenetic Regulation of Gene Expression in Mammalian Species
179
8 Regulation of Genome Activity and Genetic Networks in Mammals
201
9 Inducing Alterations in the Mammalian Genome for Investigating the Functions of Genes
221
13 Evolution of the Mammalian Karyotype
317
14 Comparative Gene Mapping Chromosome Painting and the Reconstruction of the Ancestral Mammalian Karyotype
349
From Computational Analysis through to Integrated Systems
393
16 Genetic Databases
411
17 Gene Predictions and Annotations
429
18 Genomic Research and Progress in Understanding Inherited Disorders in Humans and Other Mammals
449
19 Pharmacogenomics
477
20 Genome Scanning for Quantitative Trait Loci
507

Prokaryote and Eukaryote Perspectives
263
11 Elements and Mechanisms of Genome Change
279
12 DNA Sequence Evolution and Phylogenetic Footprinting
301
21 Mammalian Population Genetics and Genomics
539
Index
585
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