Cellular Aging and Cell Death

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Nikki J. Holbrook, George R. Martin, Richard A. Lockshin
John Wiley & Sons, Dec 20, 1995 - Science - 336 pages
Cellular AGING AND CELL DEATH

Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin

Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext.

Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence.

Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases.

One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging.

Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.
 

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Contents

Mitochondrial DNA Mutations and Aging
19
Protein Damage and Oxidative Stress
35
Immune Function Cell Death and Aging
51
Reduction in the Heat Shock Response
67
The Molecular and Cellular Biology of Aging in the Cardiovascular System
81
MOLECULAR MECHANISMS CONTROLLING CELLULAR SENESCENCE
109
Telomeres and Telomerase in Cell Senescence and Immortalization
123
EF1aS1 Gene Family and Regulation of Protein Synthesis During Aging
139
Mechanisms of Escaping Senescence in Human Diploid Cells
153
MECHANISMS AND ROLE
167
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About the author (1995)

Nikki J. Holbrook and George R. Martin are the authors of Cellular Aging and Cell Death, published by Wiley.

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