Hematology: Clinical Principles and Applications

Front Cover
Elsevier Health Sciences, Jan 1, 2007 - Medical - 816 pages
This comprehensive text examines normal hematopoiesis through diseases of erythroid, myeloid, lymphoid and megakaryocytic origins. Hemostasis and coagulation theory, testing, and instrumentation are also thoroughly discussed. Beautiful full-color illustrations throughout the text enhance comprehension and allow students to realistically visualize hematology concepts.

Detailed, full-color illustrations appear near hematology concept discussions to visually support comprehension and recognition.Opening Case Studies present real-life scenarios to apply concepts presented in each chapter.Learning Objectives and Review Questions work together to list expected outcomes and then test those concepts for each chapter.A Bulleted Summary highlights the key concepts at the end of each chapter.Hematology/Hemostasis Reference Ranges inside the front and back covers provide quick reference.

Three new chapters detail significant information: An Overview of Clinical Laboratory Hematology, Hematology in Selected Populations, and Monitoring Anticoagulant Therapy.All chapters have been revised to feature the most current technology and research updates.The included Glossary of Terms and consistent pedagogy ensure a cohesive, effective tool for learning.Two well-respected editors contributed more significantly to this third edition: George Fritsma shared his expertise for the Hemostasis section and Kathy Doig managed the pedagogical features.
 

Contents

Introduction to Hematology
1
An Overview of Clinical Laboratory Hematology
5
Safety in the Hematology Laboratory
7
Specimen Collection
17
Care and Use of the Microscope
30
Quality Assurance
39
Hematopoiesis
50
Morphology and Function of Cellular Components
51
Hemoglobinopathies Structural Defects in Hemoglobin
333
Thalassemias
355
Leukocyte Disorders
373
Introduction to Leukocyte Neoplasms
389
Cytochemistry
398
Cytogenetics
407
Molecular Diagnostics in the Clinical Laboratory
424
Flow Cytometric Analysis in Hematologic Disorders
451

Hematopoietic Theory
57
Erythrocyte Production and Destruction
77
Metabolism of the Erythrocyte
94
Hemoglobin Metabolism
105
Iron Metabolism
116
Leukopoiesis
124
Platelet Production Structure and Function
141
Routine Laboratory Evaluation of Blood Cells
160
Examination of the Peripheral Blood Smear and Correlation with the Complete Blood Count
175
Bone Marrow Overview
193
Body Fluid Examination
205
PartV Erythrocyte Disorders
219
Disorders of Iron and Heme Metabolism
232
Anemias Caused by Defects of DNA Metabolism
248
Bone Marrow Failure
259
Introduction to Increased Destruction of Erythrocytes
271
Intracorpuscular Defects Leading to Increased Erythrocyte Destruction
286
Extracorpuscular Defects Leading to Increased Erythrocyte DestructionNonimmune Causes
313
Extracorpuscular Defects Leading to Increased Erythrocyte DestructionImmune Causes
325
Myeloproliferative Disorders
471
Myelodysplastic Syndromes
484
Acute Leukemias
496
Mature Lymphoid Neoplasms
506
Hematology in Selected Populations 541
526
Cell Counting Automation
541
Hemostasis and Thrombosis
571
Hemorrhagic Coagulation Disorders
588
Thrombosis Risk Testing
605
Thrombocytopenia and Thrombocytosis
630
Qualitative Disorders of Platelets and Vasculature
655
Laboratory Evaluation of Hemostasis
670
Monitoring Anticoagulant Therapy
700
Coagulation Instrumentation
714
Appendix Material Safety Data Sheet 729
735
Glossary
749
Index
773
Contents xiii
788
Copyright

Common terms and phrases

About the author (2007)

Dr. George Fritsma manages www.fritsmafactor.com, "The Fritsma Factor, Your Interactive Hemostasis Resource," an educational blog supported by Precision BioLogic Inc, Dartmouth, Nova Scotia. Dr. Fritsma also consults for the Laboratory Solutions Program for Developing Nations, supported by BioMedica Diagnostics, Inc., Windsor, Nova Scotia. He is a consultant for the Laboratory Medicine Division of the Pathology Department, University of Alabama at Birmingham School of Medicine, where he provides lectures for pathology residents and for hematology fellows. He is an adjunct Associate Professor for Michigan State and Rutgers University. George chairs the American Association for Clinical Chemistry Press Board and is a consulting editor for the Clinical Laboratory Science journal and is a member of the International Society on Thrombosis and Hemostasis and the International Society for Laboratory Hematology.

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