Genetic Response to Metals"Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity." |
Contents
Effects of Antioxidants Zinc and Chelators on Free Radical Status | 21 |
The Role of Ascorbate in Metabolism and Genotoxicity | 37 |
Inactivation of Critical CancerRelated Genes by NickelInduced | 53 |
Oxidative Mechanisms of NickelII and CobaltII Genotoxicity | 69 |
The Antimutagenic Effects of Metallothionein May Involve Free | 87 |
Protection from MetalInduced DNA Damage by Metallothionein | 101 |
DNA Strand Breakage and Lipid Peroxidation as Possible | 121 |
Role of Metal in Oxidative DNA Damage by Nonmutagenic | 131 |
Variability in Clinical Expression of an XLinked Copper | 285 |
Development of CopperHistidine Treatment for Menkes Disease | 305 |
Clinical | 317 |
Biochemical and Clinical Benefits of CopperHistidine Therapy | 323 |
A CopperBinding ATPase | 343 |
An Advance in the Treatment of Wilsons Disease | 361 |
Metals and Gene Regulation | 379 |
Metal | 397 |
MetalDNA DNA Cleavage and ZincFinger Proteins | 153 |
Key Role | 185 |
Nickel Complexes in Modification of Nucleic Acids | 201 |
New Methods for Determining the Structure of DNA and DNA | 217 |
HIV1 Tat Protein Forms a ZincFingerlike Structure | 255 |
Menkes and Wilson Diseases | 275 |
Common terms and phrases
Acad accumulation AMT1 ascorbate assay base pairs Biochem Biochemistry Biol Biophys buffer Ca2+ cadmium Cancer carcinogenesis carcinogenic Cd2+ cells ceruloplasmin chelating Chem chromium(III chromosome cleavage clinical cloned complex concentration copper-histidine Cr(VI Cu-histidine Cu(II cysteine DNA binding DNA damage domain effect enzymes Figure formation free radicals Genet H₂O₂ heavy metals hepatic histidine hydroxyl radical increased induced inhibited interaction lanes LEC rats levels ligand liver mechanism Menkes disease Menkes patients metabolism metal ions metallothionein metallothionein gene Missing Nucleoside molecule mouse MREa MREd mRNA MT gene MT mRNA MT-I mutagenic mutations Natl nickel NiCR normal nuclear nuclei Nucleic Acids Nucleoside Occipital Horn penicillamine peptide peroxide phosphate presence probe Proc protein reaction reactive receptor region residues sequence shown specific strand structure studies therapy tissue toxic milk mice Toxicol transcription factor treatment uptake vitro vivo wild-type Wilson disease zinc finger zinc sulfate Zn2+