Lateral DNA Transfer: Mechanisms and ConsequencesThe fluidity of an organism's DNA is underappreciated. Surprisingly often, DNA is transferred from one organism to another, to become stably incorporated and permanently change the recipient's genetic composition. This process is called "lateral" or "horizontal" transfer, in contrast with the "vertical" inheritance of genes by parental descent. This is a book about how lateral transfer occurs, the extent to which it happens, and its implications for our understanding of biology. Whole genome sequencing has begun to reveal an extensive role for lateral DNA transfer in genome evolution. The molecular machinery used to transfer DNA is coming into focus and the transfer process is now known to be at work in the emergence of new infections that threaten human populations. Lateral DNA Transfer: Mechanisms and Consequences is a readable synthesis that will intrigue and educate biologists in many fields, from students to established investigators. |
Contents
| 28 | |
| 35 | |
| 66 | |
PHAGE TRANSDUCTION AND BACTERIAL PATHOGENESIS | 73 |
MICROBIAL GENOMES AND DNA EXCHANGE | 129 |
GENE TRANSFER BY RETROVIRUSES | 169 |
LATERAL DNA TRANSFER AND THE AIDS EPIDEMIC | 213 |
GENES FLOATING ON A SEA OF RETROTRANSPOSONS | 239 |
MARINERS | 273 |
FLUIDITY | 303 |
A TRANSPOSON PROGENITOR OF THE VERTEBRATE IMMUNE | 339 |
DNA TRANSFER AMONG THE DOMAINS OF LIFE | 365 |
CONTROLLING MOBILE ELEMENT ACTIVITY | 387 |
THEMES AND EVOLUTIONARY | 417 |
Index | 437 |
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Common terms and phrases
acid active antibiotic antibiotic-resistance antigen Archaea bacteria bacteriophage binding cDNA cellular Chapter chromosome cleavage coli complex conjugative plasmid contain copies diverse DNA ends DNA sequences DNA strand DNA transposons domain double-stranded Drosophila encode enzymes eukaryotic example excision FIGURE flanking function gene transfer genetic genome sequence group II introns homologous host cell host DNA human genome immune system infection inhibitors initially insertion integrase integration integron involves lateral DNA transfer lateral transfer mechanism membrane methylation Microbiol mobile DNA mobile elements mobile introns molecular molecules mRNA mutations Natl non-LTR retrotransposons operon organisms particles pathogenicity islands pathway phage plants posons prokaryotes proteins provirus reaction rearrangements receptor recombination repair repeats replication repressor resistance retroelement retrotransposons retroviral retroviruses reverse transcription segments species splicing strains structure studies synthesis T-DNA target DNA Tc1/mariner tion trans transduction transposase transposition transposon tRNA types VDJ recombination viral virus viruses yeast
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