Photostability of Drugs and Drug Formulations, Second EditionHanne Hjorth Tonnesen Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource. The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features |
Contents
Chapter 2 Photophysical and Photochemical Aspects of Drug Stability | 9 |
Chapter 3 Standardization of Kinetic Studies of Photodegradation Reactions | 41 |
Chapter 4 Rationalizing the Photochemistry of Drugs | 67 |
Chapter 5 Technical Requirements and Equipment for Photostability Testing | 111 |
Design and Interpretation of Tests on New Drug Substances and Dosage Forms | 137 |
Chapter 7 The Questions Most Frequently Asked | 161 |
Chapter 8 Inconsistencies and Deficiencies in Current Official Regulations Concerning Photolytic Degradation of Drugs | 173 |
Chapter 9 Biological Effects of Combinations of Drugs and Light | 189 |
Chapter 12 Photochemical and Photophysical Methods Used in Study of Drug Photoreactivity | 255 |
Chapter 13 Addressing the Problem of Light Instability during Formulation Development | 285 |
Chapter 14 Photostability of Parenteral Products | 303 |
Chapter 15 Photoactivated Drugs and Drug Formulations | 331 |
Chapter 16 Formulation Approaches for Improving Solubility and Its Impact on Drug Photostability | 351 |
Useful Terms and Expressions in the Photoreactivity Testing of Drugs | 373 |
Relevant Literature on the Photostability of Specific Drug Substances and Drug Formulations | 377 |
415 | |
A Test Case | 213 |
Chapter 11 Screening Dyes Drugs and Dietary Supplements for Ocular Phototoxicity | 235 |
Back cover | 437 |
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Photostability of Drugs and Drug Formulations, Second Edition Hanne Hjorth Tonnesen No preview available - 2004 |
Common terms and phrases
2ND EDITION absorbed absorption spectrum Acetonitrile acid Acta actinometer antimalarial aqueous solution Biol biological Biomed cells Chem chemical Chignell chloroquine chlorpromazine compounds concentration container cyclodextrin decomposition degradation products determined DRUG FORMULATIONS drug molecule drug products drug substance DRUGS AND DRUG effect electron emission energy excipients excited Figure filter flash photolysis fluorescent formation free radicals guideline injection irradiation kinetics lamp laser flash lens light exposure light sources liposomes measured mechanism mefloquine membrane molecular Moore Navaratnam nifedipine ocular oxidation packaging parenteral Pharm pharmaceutical Pharmazie photo-oxidation Photobiol Photochemical degradation photochemical reaction photochemical stability Photochemistry photodecomposition photodegradation photodynamic therapy photolabile photolytic photophysical photoproducts photoreactivity photosensitized PHOTOSTABILITY OF DRUGS photostability testing phototoxicity porphyrins quantum yield quinine radiation reactive Reisch sample Scheme sensitizer singlet oxygen solid solubility solvent specific spectral distribution storage studies sulfamethoxazole sunlight temperature tissue Tønnesen triplet vitro vivo wavelength xenon