GABA and the Basal GangliaJ. M. Tepper, E. D. Abercrombie, J. P. Bolam Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field. * Reviews the anatomy, physiology and pharmacology of the basal ganglia itself in addition to focusing on the GABAergic circuitry of the basal ganglia* Authors of each chapter leading internationally acclaimed experts in basal ganglia research |
Contents
GABAergic Microcircuits of the Basal Ganglia | 89 |
GABAergic Neurotransmission in the Basal Ganglia | 227 |
Systems Level Aspects of GABA in the Basal Ganglia | 285 |
Subject Index | 331 |
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Common terms and phrases
acid activity afferents agonist antagonist axon baclofen basal ganglia Bevan bicuculline Bolam Brain Res channels ClÀ Comp cortex cortical dendrites Deniau depolarizing dopamine dopaminergic neurons dystonia effects evoked excitatory expression extrasynaptic firing rate functional GABA GABA release GABAA receptor GABAA receptor subunit GABAB GABAB(1 GABAergic GABAergic neurons gene globus pallidus glutamate glutamatergic GPe neurons Hikosaka Huntington’s disease hyperpolarizing increased indirect pathway inhibition inhibitory interactions interneurons intracellular IPSCs IPSPs KCC2 Kita Kitai mediated membrane modulation monkey motor movement mRNA muscimol neostriatum Neurochem Neurophysiol Neurosci nigra pars reticulata output Parkinson’s disease parvalbumin Pharmacol Physiol postsynaptic potential presynaptic primate protein rat substantia nigra responses role rons saccadic Schousboe Smith SNr cells Sp cells spiny neurons spiny projection neurons stimulation STN neurons striatal striatonigral striatum substantia nigra substantia nigra pars subthalamic nucleus superior colliculus symmetrical synapses synaptic Tepper terminals thalamic tion tonic vitro vivo
Popular passages
Page 40 - GABAA-R and nACh-R. (Schofield, PR, Darlison, MG, Fujita, N., Burt, DR, Stephenson, FA, Rodriguez, H., Rhee, LM, Ramachandran, J., Reale, V., Glencorse, TA, Seeburg, PH and Barnard, EA (1987) Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family.
Page 56 - Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, Bettler B 1998 GABA(B)-receptor subtypes assemble into functional heteromeric complexes.
Page 164 - Beckstead RM, Domesick VB, and Nauta WJH (1979) Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res. 175, 191-217.
Page 39 - PJ (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor a, subtype.
Page 17 - Iversen LL and Johnston GAR (1971) GABA uptake in rat central nervous system: Comparison of uptake in slices and homogenates and the effects of some inhibitors.
Page 208 - Wallace, DM, Magnuson, DJ and Gray, TS (1992) Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat. Brain Res. Bull., 28: 447-454.
Page 17 - Iversen, LL and Bloom, FE (1972) Studies of the uptake of 3H-GABA and (3H)glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography. Brain Res., 41: 131-143.
Page 77 - Barnard, EA, Skolnick, P., Olsen, RW, Mohler, H., Sieghart, W.. Biggio. G.. Braestrup, C., Bateson.
Page 222 - Hikosaka, O., Takikawa, Y. and Kawagoe, R. (2000) Role of the basal ganglia in the control of purposive saccadic eye movements.