Mammalian GenomicsAnatoly Ruvinsky, Jennifer A. Marshall Graves Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse, and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion, and lab animals. Contributors include leading researchers from Europe, the U.S., Australia, and Japan, to provide a major reference work. The book covers structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, the transcriptome, the proteome, evolution of DNA sequences, comparative chromosome mapping and painting, genome analysis and bioinformatics, genome databases, gene prediction and the use of genomic information to understand inherited diseases, pharmacogenomics, and mammalian population genetics and genomics. |
Contents
1 Linkage Mapping | 1 |
2 Mapping Genomes at the Chromosome Level | 23 |
3 Mapping Genomes at the Molecular Level | 67 |
4 DNA Sequence of the Human and Other Mammalian Genomes | 87 |
5 The Transcriptome | 117 |
6 The Proteome | 153 |
Epigenetic Regulation of Gene Expression in Mammalian Species | 179 |
8 Regulation of Genome Activity and Genetic Networks in Mammals | 201 |
13 Evolution of the Mammalian Karyotype | 317 |
14 Comparative Gene Mapping Chromosome Painting and the Reconstruction of the Ancestral Mammalian Karyotype | 349 |
From Computational Analysis through to Integrated Systems | 393 |
16 Genetic Databases | 411 |
17 Gene Predictions and Annotations | 429 |
18 Genomic Research and Progress in Understanding Inherited Disorders in Humans and Other Mammals | 449 |
19 Pharmacogenomics | 477 |
20 Genome Scanning for Quantitative Trait Loci | 507 |
9 Inducing Alterations in the Mammalian Genome for Investigating the Functions of Genes | 221 |
Prokaryote and Eukaryote Perspectives | 263 |
11 Elements and Mechanisms of Genome Change | 279 |
12 DNA Sequence Evolution and Phylogenetic Footprinting | 301 |
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Common terms and phrases
Academy of Sciences acid alignment alleles analysis ancestral approach autosomes bioinformatics cattle Cell Genetics centromere chro chromatin chromo chromosome painting chromosome rearrangements clones comparative genomics comparative map complex conserved Cytogenetics and Cell databases detect disease diversity DNA methylation DNA sequences drug elements enzyme epigenetic eukaryotic eutherian evolution evolutionary exon frequency function gene expression gene mapping gene prediction Genome Research genome sequence genotype histone homologous human chromosome human genome identified Journal karyotype linkage map loci locus Mammalian Genome mammalian species mammals markers marsupials meiotic ments methods methylation mice microarray microsatellites mosome mouse genome mutations National Academy Nature Genetics nucleotide O’Brien panel patterns peptide phenotype polymorphisms population primates profiling protein proteome radiation hybrid receptor recombination regions regulation regulatory reviewed RH map Sciences USA segments selection somatic cell splice structure studies synteny target tion transcription factors transgenic translocations vector X chromosome yeast Zhang