RetrovirusesJohn M. Coffin, Stephen H. Hughes, Harold Varmus For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role. |
Contents
| 27 | |
| 71 | |
CONTENTS | 104 |
Reverse Transcriptase and the Generation of Retroviral DNA | 121 |
Integration | 161 |
Synthesis and Processing of Viral RNA | 205 |
Synthesis Assembly and Processing of Viral Proteins | 263 |
INTERMEZZO | 335 |
Retrotransposons Endogenous Retroviruses and the Evolution | 343 |
Development and Applications of Retroviral Vectors | 437 |
Pathogenesis of HIV and SIV | 587 |
Retroviral Sequences | 709 |
Retroviral Taxonomy Protein Structures Sequences | 757 |
The Best of Retrotrivia | 807 |
Index | 813 |
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Common terms and phrases
Acad activity amino acid ASLV assays assembly avian binding Biol budding cellular Chem cleavage complex core cytoplasm deletion dimer DNA ends DNA polymerase DNA synthesis domain efficiency elements encoded enhancer Env proteins envelope glycoprotein enzyme frameshifting function fusion Gag proteins Gag-Pro-Pol gene expression genetic genome genomic RNA glycoprotein H.E. Varmus HIV-1 RT host human immunodeficiency virus immunodeficiency virus type inhibitors integrase integration interactions long terminal repeat mediate membrane MMTV molecular molecules Moloney murine leukemia mouse mRNA murine leukemia virus mutations Natl nuclear Nucleic Acids nucleotides oncogene packaging peptide polyprotein precursor primer Proc protease protein provirus quences receptor recombination region replication residues retroviral retroviruses reverse transcriptase RNase H role Rous sarcoma virus S.P. Goff sequences specific splicing strand transfer structure substrate target template tion trans trans-activation transcription factors tRNA tumor viral DNA ends virion Virol Virology viruses vitro vivo
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