Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical ApplicationsAcute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists. |
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Page 8
... hepatocytes continuously exposed to IL - 6 became desensitized to IL - 6 , and SIL6 - R reconstituted their responsiveness to IL - 6.56 It is likely that hepatocytes are usually not exposed to individual factors , but , rather , to ...
... hepatocytes continuously exposed to IL - 6 became desensitized to IL - 6 , and SIL6 - R reconstituted their responsiveness to IL - 6.56 It is likely that hepatocytes are usually not exposed to individual factors , but , rather , to ...
Page 10
... hepatocyte cultures , dexamethasone alone was found to cause moderate induction of SAA and to synergize with IL - 6 ... hepatocytes , " a somewhat surprising finding in view of the downregulatory effect of histamine on IL - 6 binding in ...
... hepatocyte cultures , dexamethasone alone was found to cause moderate induction of SAA and to synergize with IL - 6 ... hepatocytes , " a somewhat surprising finding in view of the downregulatory effect of histamine on IL - 6 binding in ...
Page 11
... hepatocytes from inflamed rabbits.89 Studies employing the technique of gene transfection90 and subcellular fractionation " 1 have indicated that pentameric CRP is retained within the endoplastic reticulum of the resting hepatocyte ...
... hepatocytes from inflamed rabbits.89 Studies employing the technique of gene transfection90 and subcellular fractionation " 1 have indicated that pentameric CRP is retained within the endoplastic reticulum of the resting hepatocyte ...
Page 12
... hepatocyte membrane . 103 It has also been postulated that qualitative alterations of APP might be secondary to ... hepatocytes at the biosynthetic level following cytokine induction . 107 These results were later confirmed in human ...
... hepatocyte membrane . 103 It has also been postulated that qualitative alterations of APP might be secondary to ... hepatocytes at the biosynthetic level following cytokine induction . 107 These results were later confirmed in human ...
Page 16
... hepatocytes , FEBS Lett . , 232 , 347 , 1988 . 42. Magielska - Zero , D. , Bereta , J. , Czuba - Pelech , B. , Pajdak , W. , Gauldie , J. , and Koj , A. , Inhibitory effect of human recombinant interferon gamma on synthesis of acute ...
... hepatocytes , FEBS Lett . , 232 , 347 , 1988 . 42. Magielska - Zero , D. , Bereta , J. , Czuba - Pelech , B. , Pajdak , W. , Gauldie , J. , and Koj , A. , Inhibitory effect of human recombinant interferon gamma on synthesis of acute ...
Contents
Chapter 18 | 321 |
Chapter 19 | 329 |
Chapter 20 | 343 |
Regulation of CReactive Protein Haptoglobin and Hemopexin Gene | 365 |
Chapter 22 | 397 |
Chapter 24 | 412 |
Transcriptional Regulation of the Human C3 Gene | 425 |
Chapter 25 | 443 |
Chapter 6 | 107 |
Chapter 7 | 117 |
Chapter 8 | 149 |
Chapter 9 | 169 |
Chapter 10 | 185 |
Chapter 11 | 207 |
Chapter 12 | 223 |
Chapter 13 | 239 |
Chapter 14 | 255 |
Chapter 15 | 275 |
Chapter 16 | 289 |
Chapter 17 | 309 |
Chapter 26 | 467 |
Chapter 27 | 495 |
Chapter 28 | 511 |
Chapter 29 | 529 |
Chapter 30 | 547 |
Chapter 31 | 559 |
Chapter 32 | 581 |
Chapter 33 | 603 |
Chapter 35 | 633 |
Glycoforms of aAcid Glycoprotein as Disease Markers | 651 |
INDEX | 665 |
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Common terms and phrases
a₂-M Acad activity acute phase proteins acute phase response addition albumin amino acid analysis Baumann binding Biochem Biol biological blood C-reactive protein C/EBP cDNA cell lines changes Chem complement complex concentration containing culture cytokines determined domain effect elements expression factor fibrinogen Figure function gene gene expression glucocorticoids glycoprotein glycosylation growth haptoglobin Hep G2 hepatic hepatocytes hepatoma cells human identified Immunol increase indicated induced inflammation inhibition inhibitor injection interaction interleukin-6 involved isolated levels liver major mechanism mediated mice molecular molecule mouse mRNA murine necrosis normal nuclear observed peptide plasma proteins present primary Proc production promoter proteinase inhibitors receptor References region regulation reported residues role Schreiber secretion sequence serpins serum serum amyloid showed shown signal similar specific stimulation structure studies suggested synthesis thiostatin tissue transcription transthyretin tumor vitro vivo