Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical ApplicationsAcute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists. |
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Page 24
... liver . They calculated the rates of synthesis of plasma proteins in the livers of healthy rats from the total body pools and the turnover of injected radioactive proteins . Using the constant rate of synthesis of transferrin during the ...
... liver . They calculated the rates of synthesis of plasma proteins in the livers of healthy rats from the total body pools and the turnover of injected radioactive proteins . Using the constant rate of synthesis of transferrin during the ...
Page 26
... liver for some intracellular proteins are also influenced by the acute phase response1s ( Figure 5B ) . Levels of mRNA for ornithine transcarbamoylase decreased dramatically in rat liver immediately after induction of inflammation ...
... liver for some intracellular proteins are also influenced by the acute phase response1s ( Figure 5B ) . Levels of mRNA for ornithine transcarbamoylase decreased dramatically in rat liver immediately after induction of inflammation ...
Page 28
... liver of rats suffering an acute inflammation . Rates of incorporation of L- [ 1-14C ] leucine into plasma ... liver is the major site of synthesis of acute phase proteins ( reviewed in Chapter 3 of this volume ) . Since injury to ...
... liver of rats suffering an acute inflammation . Rates of incorporation of L- [ 1-14C ] leucine into plasma ... liver is the major site of synthesis of acute phase proteins ( reviewed in Chapter 3 of this volume ) . Since injury to ...
Page 30
... Liver During the Acute Phase Response mRNA a2u - globulin Retinol - binding protein Transthyretin Ornithine transcarbamoylase Albumin Apolipoprotein AIV Upper threshold for half - life ( h ) a 229a76 32 20 To estimate the upper ...
... Liver During the Acute Phase Response mRNA a2u - globulin Retinol - binding protein Transthyretin Ornithine transcarbamoylase Albumin Apolipoprotein AIV Upper threshold for half - life ( h ) a 229a76 32 20 To estimate the upper ...
Page 31
... liver of rats after injection of human recombinant interleukin - la □ ) or 0.9 % NaCl ( ) . Rats were injected intraperitoneally with 4500 units of interleukin - 1 in 1 ml of 0.9 % NaCl , or 1 ml of 0.9 % NaCl , at 0 , 2 , and 4 h and ...
... liver of rats after injection of human recombinant interleukin - la □ ) or 0.9 % NaCl ( ) . Rats were injected intraperitoneally with 4500 units of interleukin - 1 in 1 ml of 0.9 % NaCl , or 1 ml of 0.9 % NaCl , at 0 , 2 , and 4 h and ...
Contents
Chapter 18 | 321 |
Chapter 19 | 329 |
Chapter 20 | 343 |
Regulation of CReactive Protein Haptoglobin and Hemopexin Gene | 365 |
Chapter 22 | 397 |
Chapter 24 | 412 |
Transcriptional Regulation of the Human C3 Gene | 425 |
Chapter 25 | 443 |
Chapter 6 | 107 |
Chapter 7 | 117 |
Chapter 8 | 149 |
Chapter 9 | 169 |
Chapter 10 | 185 |
Chapter 11 | 207 |
Chapter 12 | 223 |
Chapter 13 | 239 |
Chapter 14 | 255 |
Chapter 15 | 275 |
Chapter 16 | 289 |
Chapter 17 | 309 |
Chapter 26 | 467 |
Chapter 27 | 495 |
Chapter 28 | 511 |
Chapter 29 | 529 |
Chapter 30 | 547 |
Chapter 31 | 559 |
Chapter 32 | 581 |
Chapter 33 | 603 |
Chapter 35 | 633 |
Glycoforms of aAcid Glycoprotein as Disease Markers | 651 |
INDEX | 665 |
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Common terms and phrases
a₂-M Acad activity acute phase proteins acute phase response addition albumin amino acid analysis Baumann binding Biochem Biol biological blood C-reactive protein C/EBP cDNA cell lines changes Chem complement complex concentration containing culture cytokines determined domain effect elements expression factor fibrinogen Figure function gene gene expression glucocorticoids glycoprotein glycosylation growth haptoglobin Hep G2 hepatic hepatocytes hepatoma cells human identified Immunol increase indicated induced inflammation inhibition inhibitor injection interaction interleukin-6 involved isolated levels liver major mechanism mediated mice molecular molecule mouse mRNA murine necrosis normal nuclear observed peptide plasma proteins present primary Proc production promoter proteinase inhibitors receptor References region regulation reported residues role Schreiber secretion sequence serpins serum serum amyloid showed shown signal similar specific stimulation structure studies suggested synthesis thiostatin tissue transcription transthyretin tumor vitro vivo