Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical ApplicationsAcute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists. |
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Page 6
... Mouse + Rat Note : 0 +++ 1 ++ +++ ND ? CRP ( − ) ( + ) SAP α2 - M Tf 0 ? 0 ++ ? 0 +++ +++ ++ ND no significant change increase by about twofold increase about two- to tenfold increase by 100 - fold or more decrease not detected in ...
... Mouse + Rat Note : 0 +++ 1 ++ +++ ND ? CRP ( − ) ( + ) SAP α2 - M Tf 0 ? 0 ++ ? 0 +++ +++ ++ ND no significant change increase by about twofold increase about two- to tenfold increase by 100 - fold or more decrease not detected in ...
Page 10
... mouse hepatocytes , " a somewhat surprising finding in view of the downregulatory effect of histamine on IL - 6 binding in Hep G2 cells.72 3. Intracellular Events The specific signal transduction mechanisms which mediate APP induction ...
... mouse hepatocytes , " a somewhat surprising finding in view of the downregulatory effect of histamine on IL - 6 binding in Hep G2 cells.72 3. Intracellular Events The specific signal transduction mechanisms which mediate APP induction ...
Page 12
... mouse primary hepatocyte cultures from rat a1 - acid glycoprotein transgenic mice , and could be induced by a number of cytokines and glucocorticoids , some of them acting directly and some modulating the effects of the others . 108 IL ...
... mouse primary hepatocyte cultures from rat a1 - acid glycoprotein transgenic mice , and could be induced by a number of cytokines and glucocorticoids , some of them acting directly and some modulating the effects of the others . 108 IL ...
Page 54
... MOUSE , C57 black × CBA mice . Ten μg of total RNA per track . ( A , B ) Hybridization with a rat transferrin cDNA probe ; ( C , D ) hybridization with a pig transferrin cDNA probe . The positions of 28 S and 18 S ribosomal RNA bands ...
... MOUSE , C57 black × CBA mice . Ten μg of total RNA per track . ( A , B ) Hybridization with a rat transferrin cDNA probe ; ( C , D ) hybridization with a pig transferrin cDNA probe . The positions of 28 S and 18 S ribosomal RNA bands ...
Page 68
Andrzej Mackiewicz, Irving Kushner, Heinz Baumann. Human Sheep Rabbit Rat Mouse Chicken Human Sheep Rabbit Rat Mouse Chicken Presegment Mature Protein ---- disordered -- ¬ -B - strand A - 1 MASHRLLLLC LAGLVFVSEA GPT GTGE SKCPLMVKVL ...
Andrzej Mackiewicz, Irving Kushner, Heinz Baumann. Human Sheep Rabbit Rat Mouse Chicken Human Sheep Rabbit Rat Mouse Chicken Presegment Mature Protein ---- disordered -- ¬ -B - strand A - 1 MASHRLLLLC LAGLVFVSEA GPT GTGE SKCPLMVKVL ...
Contents
Chapter 18 | 321 |
Chapter 19 | 329 |
Chapter 20 | 343 |
Regulation of CReactive Protein Haptoglobin and Hemopexin Gene | 365 |
Chapter 22 | 397 |
Chapter 24 | 412 |
Transcriptional Regulation of the Human C3 Gene | 425 |
Chapter 25 | 443 |
Chapter 6 | 107 |
Chapter 7 | 117 |
Chapter 8 | 149 |
Chapter 9 | 169 |
Chapter 10 | 185 |
Chapter 11 | 207 |
Chapter 12 | 223 |
Chapter 13 | 239 |
Chapter 14 | 255 |
Chapter 15 | 275 |
Chapter 16 | 289 |
Chapter 17 | 309 |
Chapter 26 | 467 |
Chapter 27 | 495 |
Chapter 28 | 511 |
Chapter 29 | 529 |
Chapter 30 | 547 |
Chapter 31 | 559 |
Chapter 32 | 581 |
Chapter 33 | 603 |
Chapter 35 | 633 |
Glycoforms of aAcid Glycoprotein as Disease Markers | 651 |
INDEX | 665 |
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Common terms and phrases
a₂-M Acad activity acute phase proteins acute phase response addition albumin amino acid analysis Baumann binding Biochem Biol biological blood C-reactive protein C/EBP cDNA cell lines changes Chem complement complex concentration containing culture cytokines determined domain effect elements expression factor fibrinogen Figure function gene gene expression glucocorticoids glycoprotein glycosylation growth haptoglobin Hep G2 hepatic hepatocytes hepatoma cells human identified Immunol increase indicated induced inflammation inhibition inhibitor injection interaction interleukin-6 involved isolated levels liver major mechanism mediated mice molecular molecule mouse mRNA murine necrosis normal nuclear observed peptide plasma proteins present primary Proc production promoter proteinase inhibitors receptor References region regulation reported residues role Schreiber secretion sequence serpins serum serum amyloid showed shown signal similar specific stimulation structure studies suggested synthesis thiostatin tissue transcription transthyretin tumor vitro vivo