Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical ApplicationsAcute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists. |
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Results 1-5 of 74
Page 9
... studies of the effects of cytokine combinations on plasma protein production by human hepatoma cell lines lead to three major conclusions . ( 1 ) The different plasma proteins respond differently to different combinations of cytokines ...
... studies of the effects of cytokine combinations on plasma protein production by human hepatoma cell lines lead to three major conclusions . ( 1 ) The different plasma proteins respond differently to different combinations of cytokines ...
Page 10
... studies of the induction of human C1 Inh and CRP . Both IL - 6 and INFy induced C1 Inh , while IL1 alone had only a marginal effect on the production of this protein.62 However , in combination , IL - 1 inhibited the upregulating effect ...
... studies of the induction of human C1 Inh and CRP . Both IL - 6 and INFy induced C1 Inh , while IL1 alone had only a marginal effect on the production of this protein.62 However , in combination , IL - 1 inhibited the upregulating effect ...
Page 11
... studies have suggested that processing or stabilization of mRNAs for various APP may play a role in inducing some APP changes . 84-87 In addition , translational regulation has been implicated . 63,88 The process of CRP secretion , as ...
... studies have suggested that processing or stabilization of mRNAs for various APP may play a role in inducing some APP changes . 84-87 In addition , translational regulation has been implicated . 63,88 The process of CRP secretion , as ...
Page 13
... studies of the role of cytokines in the pathogenesis of somnolence114 have shown that IL - 1α , IL - 1ẞ , TNFα , and INFα2 , when injected into the lateral ventricle of rabbits , enhanced non - REM sleep while inhibiting REM sleep ...
... studies of the role of cytokines in the pathogenesis of somnolence114 have shown that IL - 1α , IL - 1ẞ , TNFα , and INFα2 , when injected into the lateral ventricle of rabbits , enhanced non - REM sleep while inhibiting REM sleep ...
Page 14
... studies to be reflected at the clinical level , leading to different patterns of APP changes . Indeed , it is well recognized clinically that not all acute phase phenomena occur in all sick people ; e.g. , in many afebrile patients ...
... studies to be reflected at the clinical level , leading to different patterns of APP changes . Indeed , it is well recognized clinically that not all acute phase phenomena occur in all sick people ; e.g. , in many afebrile patients ...
Contents
Chapter 18 | 321 |
Chapter 19 | 329 |
Chapter 20 | 343 |
Regulation of CReactive Protein Haptoglobin and Hemopexin Gene | 365 |
Chapter 22 | 397 |
Chapter 24 | 412 |
Transcriptional Regulation of the Human C3 Gene | 425 |
Chapter 25 | 443 |
Chapter 6 | 107 |
Chapter 7 | 117 |
Chapter 8 | 149 |
Chapter 9 | 169 |
Chapter 10 | 185 |
Chapter 11 | 207 |
Chapter 12 | 223 |
Chapter 13 | 239 |
Chapter 14 | 255 |
Chapter 15 | 275 |
Chapter 16 | 289 |
Chapter 17 | 309 |
Chapter 26 | 467 |
Chapter 27 | 495 |
Chapter 28 | 511 |
Chapter 29 | 529 |
Chapter 30 | 547 |
Chapter 31 | 559 |
Chapter 32 | 581 |
Chapter 33 | 603 |
Chapter 35 | 633 |
Glycoforms of aAcid Glycoprotein as Disease Markers | 651 |
INDEX | 665 |
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Common terms and phrases
a₂-M Acad activity acute phase proteins acute phase response addition albumin amino acid analysis Baumann binding Biochem Biol biological blood C-reactive protein C/EBP cDNA cell lines changes Chem complement complex concentration containing culture cytokines determined domain effect elements expression factor fibrinogen Figure function gene gene expression glucocorticoids glycoprotein glycosylation growth haptoglobin Hep G2 hepatic hepatocytes hepatoma cells human identified Immunol increase indicated induced inflammation inhibition inhibitor injection interaction interleukin-6 involved isolated levels liver major mechanism mediated mice molecular molecule mouse mRNA murine necrosis normal nuclear observed peptide plasma proteins present primary Proc production promoter proteinase inhibitors receptor References region regulation reported residues role Schreiber secretion sequence serpins serum serum amyloid showed shown signal similar specific stimulation structure studies suggested synthesis thiostatin tissue transcription transthyretin tumor vitro vivo