Water and Biological Macromolecules
Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging.
Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists.
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Thermodynamic and dynamic properties of water
Hydration of amino acids in protein crystals
Hydration of protein secondary structures the role
Structural water bridges in nucleic acids
Hydration sites and hydration bridges around DNA helices
Light scattering spectroscopy studies of the water molecules
Polysaccharide interactions with water
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Acta analysis atoms base bilayers binding Biol Biophys bound bridges calculations cell Cevc charged Chem complex conformation contribution corresponding crystal structure crystalline density dependence determined diffraction distance distribution effects electron energy Equation et al example experimental Figure force function Gibbs energy given groove groups headgroup helices helix hydration shell hydrogen bonds hydrophilic hydrophobic increases indicate interactions interfacial involved ions lines lipid liquid measurements membrane methods molecular dynamics Nature neutron nucleic acids observed obtained occur orientation oxygen pairs phase phosphate Phys polar polysaccharides positions potential Press primary properties protein quantum mechanical Raman spectroscopy refinement region relative relaxation repulsion residues resolution respectively shown similar simulation solution solvation solvent stability studies sugar surface Table temperature tion transition unit water molecules X-ray