Water and Biological MacromoleculesWater and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging. Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists. |
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Contents
Water structure | 3 |
Thermodynamic and dynamic properties of water | 42 |
Dynamic properties | 48 |
Aqueous solutions of simple hydrophobic solutes | 55 |
Hydration of amino acids in protein crystals | 81 |
Highresolution | 98 |
Hydration of protein secondary structures the role | 148 |
Molecular dynamics simulations on the hydration structure | 165 |
Lipid aggregation in water | 373 |
Hydration force | 374 |
Relevance of lipid hydration | 376 |
Thermodynamics | 391 |
Hydration forces C J van Oss | 393 |
Theory | 394 |
Negative interfacial tensions and polar repulsion | 401 |
Quantitative expression of hydrophilicity and hydrophobicity | 403 |
Structural water bridges in nucleic acids | 226 |
Hydration sites and hydration bridges around DNA helices | 244 |
Light scattering spectroscopy studies of the water molecules | 266 |
Polysaccharide interactions with water | 295 |
The role of structural water molecules in proteinsaccharide | 321 |
Enzymes | 324 |
Lectins | 326 |
Discussion and Conclusion | 334 |
Lipid hydration G Cevc | 338 |
Sources of lipid hydration | 340 |
Temperature effects | 348 |
Ion and solute effects | 349 |
Modelling lipidwater interactions | 351 |
Consequences of lipid hydration | 358 |
Hydration orientation | 407 |
Consequences and examples of hydration forces | 413 |
Solvation forces in nonaqueous media | 419 |
How specific interactions overcome hydration forces | 422 |
Solvation thermodynamics of biopolymers A BenNaim | 430 |
Definitions | 431 |
The ingredients of AG | 436 |
Some illustrative numerical examples | 441 |
Critique of the group additivity assumption for the solvation Gibbs energy | 446 |
Examples of biochemical processes affected by solvation | 450 |
Solvation and structural changes in the solvent | 455 |
458 | |
461 | |
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Common terms and phrases
Acta Cryst analysis angles anionic aqueous atoms B-DNA B-form backbone base pairs Beveridge binding Biochemistry Biol Biomol Biophys Biopolymers calculations cell Cevc chain Chem Clementi complex conformation correlation counterions crystal structure crystalline crystallographic d(CGCGAATTCGCG density distance dodecamer duplex electron electrostatic Equation experimental Figure force field free energy function Gibbs energy Goodfellow H-bond helical helix hydration hydration forces hydrogen bonds hydrophilic hydrophobic ice Ih interactions interfacial ions lipid headgroups liquid macromolecules main-chain MD simulation membrane minor groove mJ/m² molecular dynamics molecular dynamics simulations Monte Carlo neutron diffraction nucleic acids nucleotide orientation oxygen phase phosphate groups phosphatidylcholine phospholipid Phys polar polymer polysaccharides potential refinement region relaxation repulsive residues Saenger side-chains solution solvation solvation Gibbs energy solvent solvent molecules solvent structure ẞ-sheet stability studies surface temperature tion water bridges water molecules water structure Westhof X-ray Z-DNA
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Page 381 - Interacting phospholipid bilayers: measured forces and induced structural changes.