Fundamentals of Inflammation

Front Cover
Charles N. Serhan, Peter A. Ward, Derek W. Gilroy
Cambridge University Press, Apr 26, 2010 - Science
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
 

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Contents

The InflAmmAToRy ResPonse An oveRvIew
1
Resolution of Acute Inflammation and wound healing
17
links between Innate and Adaptive Immunity
28
IndIvIduAl Cell TyPes
39
mast Cells as sentinels of Inflammation
65
Basophils
74
eosinophils
86
macrophages
96
Cytokines and Chemokines in Inflammation and Cancer
244
InflAmmAToRy dIseAseshIsToloGy
253
neural Inflammation Alzheimers disease and stroke
259
Rheumatoid Arthritissle
267
mediators
282
Inflammatory skin diseases
299
Inflammation in Cardiovascular diseases
317
AnImAl models of InflAmmATIon
329

lymphocytes
107
fibroblasts and stromal Cells
126
neutrophilendothelial Cell Interactions
141
ChemICAl medIAToRs
153
Cytokines and Chemokines in Inflammation
175
Therapeutic Aspects for Inflammatory
186
leukocyte Generation of Reactive oxygen species
198
Cell Adhesion molecules
208
ImmunoPhARmAColoGy
217
nonsteroidal AntiInflammatory drugs
234
28A experimental models of Glomerulonephritis
338
28B Glomerulonephritis and Ischemia Reperfusion Injury
349
Asthma
376
Animal models of Rheumatoid Arthritis
385
ocular Inflammation models
413
Atherosclerosis in experimental Animal models
427
oral Inflammation and Periodontitis
433
Pathogens and Inflammation
448
Index
457
Copyright

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About the author (2010)

Charles N. Serhan, PhD, is the Simon Gelman Professor of Anesthesia at Brigham and Women's Hospital, Director of the Center for Experimental Therapeutics and Reperfusion Injury, and Professor of Biochemistry and Molecular Pharmacology at Harvard Medical School, Cambridge, Massachusetts. He is one of the world's top researchers on inflammation and mediation.

Peter A. Ward, MD, is Stobbe Professor of Pathology at the University of Michigan Health Systems, Ann Arbor, Michigan. Dr Ward is past President of the United States and Canadian Academy of Pathology.

Derek W. Gilroy, PhD, is a lecturer in the Centre for Clinical Pharmacology, University College London, United Kingdom. He has received the Bayer Aspirin Prize and is a Wellcome Trust Research Career Development Fellow.

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