The Merkel Cell: Structure-Development-Function-CancerogenesisKlaus Baumann, Zdenek Halata, Ingrid Moll Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but their discovery has raised additional questions regarding Merkel cell function. Essential aspects of structure, development and function of normal Merkel cells and Merkel cell carcinoma are presented in short chapters, providing concise and up-to date information on this fascinating cell type. |
Contents
Merkel Nerve Endings Functioning as Mechanoreceptors in Vertebrates | 3 |
The ThreeDimensional Microanatomy of Merkel Cells | 7 |
Staining of Living Merkel Cells with FM Dyes | 13 |
Distribution of Merkel Cells in Normal Skin and Mucosae in Dogs | 19 |
Merkel Cells in Human Transplanted Flaps | 25 |
Merkel Cells in Malassez Epithellum | 29 |
Morphological Changes in Merkel Cells of Mucosa Underlying Dentures | 33 |
A Study on the Sensory System of PeriImplant Tissue Behavior of Merkel Cells and Nerve Fibers | 37 |
The Functional Significance of the Vibrissal System of Marine Mammals | 127 |
Confocal Microscopic Analysis of Merkel Innervation in the Cat Mystacial Vibrissa Follicles | 137 |
VoltageDependent Calcium Channels in Merkel Cells of Hamster Oral Mucosa | 143 |
Localization of Signal Transduction Proteins in the Merkel Cell Axon Complex | 147 |
Are Glutamate Receptors Involved in Transmission at the Junction Between Merkel Cell and Nerve Terminal? | 155 |
Glutamate ReceptorLike Immunoreactivity in Rat Vibrissal Merkel Cells | 163 |
Transduction in Merkel Cell Mechanoreceptors What is the Job of the Merkel Cell? | 169 |
Merkel Cell Carcinoma | 177 |
Merkel Nerve Endings in Sinus Hairs of Young and Aged Rats | 41 |
Immunohistochemical Characterization of Normal Canine Merkel cells | 49 |
Merkel Cells in the Human Fetal and Adult Esophagus | 57 |
Cellular Localization of PreproOrexin and Orexin Receptors OxIR and Ox2R in Merkel Cells | 65 |
Possible Functional Significance of Spatial Relationship Between Merkel Cells and Langerhans Cells in Human Hair Follicles | 71 |
Neurobiology of the Murine Pelage Hair Follicle | 79 |
Development | 87 |
Mammalian Merkel Cells Are Neural Crest Derivatives | 89 |
Merkel Cells Are Postmitotic Cells of Neural Crest Origin | 97 |
Dissociation Quantification and Culture of Normal Human Merkel Cells Among Epidermal Cell Populations Derived from Glabrous and Hairy Skin S... | 105 |
Growth of Nerve Fibers to Merkel Cells Observed in CoCulture of Sensory Ganglia and Sinus Hair Follicles | 113 |
Merkel Cell Development is Independent of L1 Adhesion Molecule | 121 |
Mechanoreceptors | 125 |
Merkel Cell Carcinoma A Short Review | 179 |
Histochemistry of Glycoconjugates in Merkel Cell Carcinomas | 187 |
Gene Expression Profiling Reveals Two Distinct Subtypes of Merkel Cell Carcinoma | 194 |
Expression of Developmentally Regulated Transcription Factors in Merkel Cell Carcinoma | 201 |
Expression Patterns of Connexins in Merkel Cell Carcinoma and Adjacent Epidermis | 217 |
Expression Patterns of Tight Junction Proteins in Merkel Cell Carcinoma | 221 |
Ganglioside Profiles of Merkel Cell Carcinoma | 225 |
MOC3I Cytokeratin 7 and SI00 Protein Immunoreactivity in Merkel Cell and Merkel Cell Carcinoma | 229 |
| 235 | |
Chemotherapy in Merkel Cell Carcinoma with Distant Metastasis Proposal of a PanEuropean Clinical Trial | 239 |
| 243 | |
| 245 | |
Other editions - View all
The Merkel Cell: Structure-Development-Function-Cancerogenesis Klaus Baumann,Zdenek Halata,Ingrid Moll No preview available - 2010 |
Common terms and phrases
anagen Anat arrows axon basal lamina basal layer Baumann Biol bulge Ca2+ Cancer co-culture culture cutaneous cytokeratin cytokeratin 20 cytoplasm Dehnhardt dense core granules dermis detected differentiation E-mail epidermal cells epidermis epithelium esophagus expression fetal fluorescence FM dyes function genes glutamate receptors hair follicle hairy skin Halata Hamburg Hartschuh human Merkel cells Iggo immunohistochemical immunohistochemistry immunoreactivity immunostaining innervation Invest Dermatol keratinocytes Langerhans cells located mammalian Merkel cells mammals marker MCC cell lines mechanoreceptors melanoma Merkel cell carcinoma Merkel nerve endings mice microscope microvilli Moll monoclonal antibody mouse mucosa Munger mystacial nerve terminals neuroendocrine cells neurofilament neuronal neuropeptides Neurosci normal number of Merkel oral orexin outer root sheath palate protein quinacrine ring sinus SCLC sections Senok sensory nerve fibers sinus hair follicles slowly adapting staining synaptic synaptophysin Tachibana Tazaki telomerase transcription factors ultrastructural Variant vibrissae whisker