Morphogenesis of Endothelium
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. Embryonic growth and differentiation essentially depend on transport of nutrients and waste through the early vasculature, and certain events in morphogenesis are thought to be influenced by the hemodynamic forces of the beating heart. The vasculature not only serves as a 'nutrient and waste pipeline' but is also a major communication system between distant organs and tissues. The vascular endothelial cell mediates vascular growth, permeability, integrity and interactions with blood cells. In most tissues the endothelium itself is highly specialized to meet the particular needs of the tissue in terms of quality and quantity of incoming and outgoing molecules and messages.
The areas covered by Morphogenesis of the Endothelium include the formation of blood vessels in embryonic tissues by vasculogenesis and angiogenesis and the differentiation of endothelium in organs. The contributors are leaders in the field of cardiovascular development, biology and pathology and have written up to date chapters on the mechanisms of blood vessel formation and function in embryos and the adult.
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abluminal adhesion molecules adult alveolar Anat angioblasts angiogenesis angiogenic antibodies aorta arteries arterioles astrocytes avian embryo basal lamina bFGF blood vessels blood-brain barrier brain cadherin capillary capillary network caveolae Cell Biol chick embryo collagen corpus luteum developmental Dieterlen-Lièvre differentiation embryo endothelial cells endothelial growth factor endothelium epithelial etal expression extracellular fenestral diaphragms fenestrated fenestrated endothelium fetal Figure function gene Gittenberger-de Groot glomerular glomeruli graft hemopoietic human induced integrins kidney layer ligands limb bud liver luminal lung lymph nodes lymphatic matrix mature mesenchymal mesoderm mice microvascular molecular mouse mRNA neural organ ovarian Palade Pardanaud PECAM-1 pericytes permeability phenotype placental plasma plexus Poelmann postnatal proliferation protein pulmonary quail regression regulation renal retina Risau role Simionescu sinusoidal endothelial cells smooth muscle cells somites sprouting structure studies tight junctions tissue tumor tyrosine kinase ultrastructural vascular endothelial growth vascular system vasculature vasculogenesis VEGF VEGF-A veins venules villi vitro vivo