Inflammatory Bowel DiseaseRichard P. MacDermott, William F. Stenson |
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Page 206
... LTB4 , and 5 - HETE concentrations 3 , 6 , and 10 times higher than those of normal tissues , 41,42 in addition to increased activity of PG synthetase . The amounts of PGE2 , PGF2a , 6 - keto - PGF1a ( the stable breakdown product of ...
... LTB4 , and 5 - HETE concentrations 3 , 6 , and 10 times higher than those of normal tissues , 41,42 in addition to increased activity of PG synthetase . The amounts of PGE2 , PGF2a , 6 - keto - PGF1a ( the stable breakdown product of ...
Page 209
... LTB4 antisera and correlated with mucosal LTB4 concentrations . These data suggest a major role for LTB4 in the inflammatory process in IBD . In fact , LTB4 is reported to be the most potent chemotactic ( ie , stimulating directional ...
... LTB4 antisera and correlated with mucosal LTB4 concentrations . These data suggest a major role for LTB4 in the inflammatory process in IBD . In fact , LTB4 is reported to be the most potent chemotactic ( ie , stimulating directional ...
Page 215
... LTB4 in patients with active UC and a drop in disease activity in 9 of 10 patients with active CD.135,136 The third potential point for drug intervention is specific inhibition of 5- lipoxygenase activity . At present the greatest ...
... LTB4 in patients with active UC and a drop in disease activity in 9 of 10 patients with active CD.135,136 The third potential point for drug intervention is specific inhibition of 5- lipoxygenase activity . At present the greatest ...
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abnormalities acid action activity addition agents alterations antibodies antigens appear associated bacterial blood cause chronic Clin clinical colonic compared complement complex component Crohn's disease cytokines cytotoxic decreased defect determined diarrhea effects enhanced epithelial cells epithelium et al evidence expression factor findings function Gastroenterology genes genetic granulomas growth human immune immune response Immunol immunologic important incidence increased induced infection inflammation inflammatory bowel disease inhibition initially injury intestinal involved isolated lamina propria lesions leukocyte levels lymphocytes macrophages markers mast cells mechanisms mediators mononuclear mucin mucosal Nature neutrophils normal observed occur patients population possible potential present production prostaglandin protein rates recent receptor regulation relatives release reported response risk role schistosomiasis secretion secretory serum shown specific stimulation studies suggest T-cell tissue ulcerative colitis vitro