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The Genetics of Inflammatory Bowel Disease
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abnormalities agents antibodies antigen associated autoantibodies autoimmune bacterial biopsy Brandtzaeg cellular chemotactic chronic Clin Exp Immunol Clin Invest clinical colitis and Crohn's collagen complement Crohn's disease cytokines cytotoxic detected diarrhea disease activity disease and ulcerative effects eicosanoids epithelial cells epithelium factor function Gastroenterology gastrointestinal genes genetic granulomas human intestinal ileal ileum immune response immune system immunocytes immunoglobulin immunologic increased induced infection inflammation inflammatory bowel disease inhibition interleukin isolated Jewell DP lamina propria lesions leukocyte leukotriene LTB4 lymphocytes macrophages markers mast cells mechanisms mediators monocytes mononuclear cells mucin mucosal mycobacteria neutrophils normal pathogenesis patients with Crohn's patients with ulcerative peptides permeability Peyer's patches production prostaglandin protein receptor rectal release result role Scand J Gastroenterol secretion secretory serum Shanahan F small bowel small intestine smooth muscle specific stimulation studies suggest sulfasalazine syndrome synthesis T-cell therapy tissue ulcerative colitis vitro vivo