Inflammatory Bowel DiseaseRichard P. MacDermott, William F. Stenson |
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Page 35
... genes , 235-240 it will be important to determine whether genetic differences in a specific mucin gene are associated with UC . Genetic and Etiologic Models There are currently several models of the genetic susceptibility to any disease ...
... genes , 235-240 it will be important to determine whether genetic differences in a specific mucin gene are associated with UC . Genetic and Etiologic Models There are currently several models of the genetic susceptibility to any disease ...
Page 36
... genes each of small effect ( hence the term polygenic ) , acting together to provide the susceptibility to disease . Only when a person has a sufficient number of these genes would he or she pass beyond a threshold and clinical disease ...
... genes each of small effect ( hence the term polygenic ) , acting together to provide the susceptibility to disease . Only when a person has a sufficient number of these genes would he or she pass beyond a threshold and clinical disease ...
Page 37
... genes ( and has CD ) , his or her relatives are more likely to have a larger number of the genes compared with relatives of a patient with only a moderate number of the risk genes ( ie , a UC patient ) . Thus , CD patients are more ...
... genes ( and has CD ) , his or her relatives are more likely to have a larger number of the genes compared with relatives of a patient with only a moderate number of the risk genes ( ie , a UC patient ) . Thus , CD patients are more ...
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abnormalities acid action activity addition agents alterations antibodies antigens appear associated bacterial blood cause chronic Clin clinical colonic compared complement complex component Crohn's disease cytokines cytotoxic decreased defect determined diarrhea effects enhanced epithelial cells epithelium et al evidence expression factor findings function Gastroenterology genes genetic granulomas growth human immune immune response Immunol immunologic important incidence increased induced infection inflammation inflammatory bowel disease inhibition initially injury intestinal involved isolated lamina propria lesions leukocyte levels lymphocytes macrophages markers mast cells mechanisms mediators mononuclear mucin mucosal Nature neutrophils normal observed occur patients population possible potential present production prostaglandin protein rates recent receptor regulation relatives release reported response risk role schistosomiasis secretion secretory serum shown specific stimulation studies suggest T-cell tissue ulcerative colitis vitro