Risk and Protective Factors in Schizophrenia: Towards a Conceptual Model of the Disease Process

Front Cover
Heinz Häfner
Springer Science & Business Media, Nov 29, 2002 - Medical - 331 pages
H. HAFNER Schizophrenia Research Unit, Central Institute of Mental Health, Mannheim, Germany The present volume contains the lectures and invited discussions of the sympo sium on "Risk and protective factors in schizophrenia - towards a conceptual model of the disease process", which was held at the International Science Forum of the University of Heidelberg from October 25 to 27, 200l. They are supple mented by a "Summary and outlook", in which Peter Jones gives a brief overview of the results and perspectives featured in the presentations and discussions. The contributions and discussions reflect the open-minded and creative atmosphere at the meeting. The systematically structured program of the symposium continued the tradition of the Search for the Causes of Schizophrenia symposia, which were th started in 1986 on the occasion of the 600 anniversary of the University of Hei delberg and which are co-organized with Prof. Wagner Farid Gattaz/Sao Paulo. The aim of these symposia and their proceedings volumes [6,8-10] has been to reflect the state of the art in schizophrenia research at their time, and they have successfully done so. In contrast, the present symposium pursued a more lim ited objective and was of a different type. It brought together, around a large table at the International Science Forum in Heidelberg, 22 invited speakers and dis cussants and an equal number of young scientists working in the research fields in question, who were thus given an opportunity to listen and to participate.

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Contents

Genetics of schizophrenia and related disorders
3
Genotypeenvironment interaction in the Finnish adoptive family study Interplay between genes and environment?
23
psychological and social risk mechanisms for psychosis
33
Developmental Disorders of the Brain
53
is there evidence for a neurodevelopmental disorder?
55
Highrisk studies and neurodevelopmental hypothesis
65
Are structural cerebral changes progressive in schizophrenia?
77
developmental disorders of the brain
93
Psychopathological Predictors of Onset and Course of Schizophrenia
185
Predicting the onset of schizophrenia
187
The early course of schizophrenia
201
Testing models of the early course of schizophrenia
223
psychopathological predictors of onset and course of schizophrenia
237
Perspectives of Neuroprotective Interventions
249
Neuroprotection in schizophrenia What does it mean? What means do we have?
251
mechanisms of action
257

Environmental Risk Factors
97
Obstetric complications maternal psychopathology and the risk of psychosis
99
Migration and the social epidemiology of schizophrenia
107
Urbanrural life as a risk factor?
117
Environmental risk factors of psychosis
127
Indicators of Schizophrenia in Childhood and Adolescence
133
Risk factors for schizophrenia in childhood and youth
135
Association between cognitive and behavioral functioning nonpsychotic psychiatric diagnoses and drug abuse in adolescence with later hospitalizatio...
157
Specificity of basic symptoms in early onset schizophrenia
171
indicators of schizophrenia in childhood and adolescence
179
avenue to neuroprotection in schizophrenia
265
Psychoprotective Factors
277
empirical evidence of efficacy and open questions
279
Cognitivebehavior therapy in the treatment of schizophrenia
289
Coping and social support as protective factors
297
Protective interventions in schizophrenia
315
Developments and Perspectives
319
Risk and protective factors in schizophrenia Towards a conceptual model of the disease process
321
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