Origins and Directions of Inflammatory Bowel Disease: Early Studies of the “Nonspecific” Inflammatory Bowel DiseasesJoseph B. Kirsner Few human illnesses today are so challenging, medically, scientifically, and socio-economically, as the "nonspecific" inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's disease. Originating several centuries ago but essentially diseases of the 20th century, often attacking children and young adults, involving all bodily systems as well as the gastrointestinal tract, ulcerative colitis and Crohn's disease have emerged in recent decades as among the more "glamorous" unsolved diseases, presenting unusual opportunities for insightful clinical and investigative study. Many of the prevailing concepts originated during the early and mid 20th century. The purpose of Origins and Directions of Inflammatory Bowel Disease is to review these earlier studies and their evolution "from the mystical to the molecular," and guide investigators and physicians through the challenging clinical and scientific maze of IBD. |
Contents
INCREASING CLINICAL RECOGNITION | |
PATHOLOGY ELECTRON MICROSCOPY ULCERATIVE | |
Crohns disease | |
EARLY CLINICAL RECOGNITION | |
MORE EARLY 20TH CENTURY REPORTS CD | |
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Origins and Directions of Inflammatory Bowel Disease: Early Studies of the ... Joseph B. Kirsner No preview available - 2013 |
Common terms and phrases
abdominal acid active allergy andthe antibodies antigen Arch associated autoantibodies autoimmunity bacterial Bargen Chicago Chir chronic ulcerative colitis cicatrizing Clin clinical colectomy coli colitis and Crohn’s colitisand colonic mucosa complications Crohn’s colitis Crohn’s disease cytokines demonstrated described diarrhea dysentery early Engl eosinophils epidemiology epithelial cells epithelium etiology experimental factors fecal Gastroenterol Gastroenterology gastrointestinal tract genetic granulomatous histologic Hospital human ileostomy Immunol immunologic implicated incidence included infection inflammation inflammatory bowel disease inthe inulcerative colitis involved JAMA Kirsner JB Kruiningen Lancet lesions London lymphocytes mast cells Mesalazine metabolism microbial Morson mucosal nonspecific ulcerative colitis normal observed ofthe colon Palmer WL pathogenesis Pathol pathology patients with Crohn’s patients with ulcerative patientswith permeability Philadelphia Proc protein psychogenic rabbits rats rectal rectum regional enteritis regional ileitis reported resection Scand serum Sinai small intestine studies sulfasalazine Surg surgical terminal ileum therapeutic therapy tothe treatment ulcerativecolitis University York