Proteome Characterization and Proteomics

Front Cover
Timothy D. Veenstra, Richard D. Smith
Academic Press, Oct 1, 2003 - Science - 413 pages
The content of this volume is designed to reach a wide audience, including those involved with relevant technologies such as electrophoresis and mass spectrometry, to those interested in how proteomics can benefit research. A wide range of techniques are discussed, each specifically designed to address different needs in proteomic analysis. The concluding chapter discusses the important issue related to handling large amounts of data accumulated in proteomic studies.
  • Discusses proteomics in the postgenomic age
  • Includes various strategies for quantitative proteomics
  • Covers the role of MS in structural functional proteomics and proteomics in drug discovery and bioinformatics

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Contents

Proteomic Analysis by TwoDimensional Polyacrylamide Gel Electrophoresis
57
HighPerformance Separations and Mass Spectrometric Methods for HighThroughput Proteomics Using Accurate Mass Tags
85
Current Strategies for Quantitative Proteomics
133
Proteome Analysis of Posttranslational Modifications
161
Mapping Protein Modifications with Liquid ChromatographyMass Spectrometry and the SALSA Algorithm
195
Emerging Role of Mass Spectrometry in Structural and Functional Proteomics
217
Application of Separation Technologies to Proteomics Research
249
Proteomics of Membrane Proteins
271
Proteomics in Drug Discovery
309
Maximizing the Amount of Protein Samples for Structure Determination
343
Proteomics and Bioinformatics
353
AUTHOR INDEX
371
SUBJECT INDEX
403
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Page 23 - D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern...
Page 18 - Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson...
Page 19 - Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E. Hendrix M. Radmacher M, Simon R. Yakhini Z, Ben-Dor A, Sampas N, Dougherty E. Wang E. Marincola F. Gooden C. Lueders J. Glatfelter A, Pollock P, Carpten J, Gillanders E, Leja D. Dietrich K, Beaudry C. Berens M, Alberts D. Sondak V.
Page 338 - Hunt, DF, Henderson, RA, Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, AL, Appella, E., and Engelhard, VH Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry.
Page 191 - Brown, PO and Botstein, D. (1999) Exploring the new world of the genome with DNA microarrays.
Page 130 - Gygi, SP, Rist, B., Gerber, SA, Turecek, F., Gelb, MH, and Aebersold, R. (1999). Quantitative analysis of complex protein mixtures using isotope-coded affinity tags.
Page 335 - The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis — preliminary findings. Electrophoresis, 20, 689-700 (2000).
Page 127 - Pacific Northwest Laboratory is operated by Battelle Memorial Institute for the US Department of Energy under Contract DE-AC06-76-RLO 1830.
Page 128 - Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T., and Mann, M. (1996). Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry.
Page 336 - An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.

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