Neuronal Nicotinic ReceptorsFrancesco Clementi, Diego Fornasari, Cecilia Gotti Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results. |
Contents
I | 3 |
III | 5 |
IV | 7 |
V | 8 |
VI | 13 |
VII | 15 |
IX | 16 |
XII | 17 |
CCXXXIX | 421 |
CCXLI | 423 |
CCXLII | 424 |
CCXLIII | 425 |
CCXLV | 426 |
CCXLVI | 427 |
CCXLIX | 428 |
CCL | 429 |
XV | 20 |
XVI | 21 |
XVII | 22 |
XVIII | 23 |
XIX | 24 |
XXI | 26 |
XXII | 33 |
XXIV | 34 |
XXV | 35 |
XXVI | 36 |
XXVII | 39 |
XXVIII | 40 |
XXIX | 41 |
XXX | 43 |
XXXII | 44 |
XXXIII | 45 |
XXXIV | 46 |
XXXV | 47 |
XXXVI | 49 |
XXXVII | 57 |
XXXIX | 59 |
XL | 60 |
XLII | 61 |
XLIII | 63 |
XLIV | 64 |
XLVI | 65 |
XLVII | 66 |
XLVIII | 68 |
XLIX | 69 |
LI | 73 |
LIII | 79 |
LV | 81 |
LVI | 82 |
LVII | 83 |
LVIII | 88 |
LIX | 89 |
LX | 91 |
LXI | 93 |
LXII | 95 |
LXIII | 96 |
LXIV | 101 |
LXV | 102 |
LXVI | 103 |
LXVII | 110 |
LXVIII | 112 |
LXIX | 123 |
LXXI | 124 |
LXXII | 125 |
LXXIII | 127 |
LXXIV | 128 |
LXXV | 131 |
LXXVI | 133 |
LXXVII | 134 |
LXXVIII | 137 |
LXXIX | 139 |
LXXX | 140 |
LXXXI | 144 |
LXXXII | 146 |
LXXXIII | 147 |
LXXXIV | 163 |
LXXXVI | 164 |
LXXXVIII | 165 |
XC | 166 |
XCI | 173 |
XCII | 174 |
XCV | 175 |
XCVI | 176 |
XCVIII | 180 |
XCIX | 182 |
CI | 184 |
CII | 185 |
CIII | 193 |
CV | 195 |
CVII | 196 |
CVIII | 197 |
CIX | 198 |
CX | 199 |
CXII | 200 |
CXIV | 201 |
CXV | 203 |
CXVII | 205 |
CXIX | 206 |
CXXI | 213 |
CXXIII | 214 |
CXXV | 215 |
CXXVI | 216 |
CXXVII | 217 |
CXXVIII | 218 |
CXXX | 223 |
CXXXI | 224 |
CXXXIII | 225 |
CXXXIV | 227 |
CXXXV | 228 |
CXXXVI | 229 |
CXXXVII | 231 |
CXXXVIII | 232 |
CXXXIX | 233 |
CXL | 234 |
CXLI | 235 |
CXLII | 236 |
CXLIII | 237 |
CXLIV | 247 |
CXLVI | 248 |
CXLVII | 249 |
CXLVIII | 250 |
CXLIX | 252 |
CL | 254 |
CLI | 257 |
CLII | 258 |
CLIII | 259 |
CLIV | 260 |
CLV | 262 |
CLVII | 271 |
CLIX | 274 |
CLX | 275 |
CLXI | 277 |
CLXII | 278 |
CLXIII | 279 |
CLXIV | 282 |
CLXV | 284 |
CLXVI | 285 |
CLXVII | 288 |
CLXVIII | 289 |
CLXIX | 290 |
CLXX | 292 |
CLXXI | 293 |
CLXXII | 301 |
CLXXIV | 304 |
CLXXV | 305 |
CLXXVI | 306 |
CLXXVII | 308 |
CLXXVIII | 310 |
CLXXIX | 312 |
CLXXX | 315 |
CLXXXI | 317 |
CLXXXII | 323 |
CLXXXIII | 325 |
CLXXXIV | 329 |
CLXXXVI | 337 |
CLXXXVIII | 338 |
CLXXXIX | 339 |
CXC | 343 |
CXCI | 345 |
CXCII | 348 |
CXCIII | 350 |
CXCIV | 351 |
CXCV | 353 |
CXCVI | 359 |
CXCVIII | 360 |
CCI | 362 |
CCII | 363 |
CCIII | 364 |
CCV | 365 |
CCVI | 366 |
CCVII | 367 |
CCIX | 368 |
CCXI | 370 |
CCXII | 372 |
CCXIII | 375 |
CCXIV | 379 |
CCXVI | 381 |
CCXVIII | 382 |
CCXIX | 383 |
CCXX | 384 |
CCXXI | 385 |
CCXXIII | 388 |
CCXXIV | 389 |
CCXXV | 390 |
CCXXVI | 392 |
CCXXVII | 393 |
CCXXVIII | 394 |
CCXXIX | 395 |
CCXXXI | 396 |
CCXXXII | 397 |
CCXXXIII | 401 |
CCXXXIV | 403 |
CCXXXV | 407 |
CCXXXVII | 419 |
CCLI | 430 |
CCLIII | 431 |
CCLIV | 432 |
CCLV | 434 |
CCLVII | 435 |
CCLX | 436 |
CCLXII | 437 |
CCLXIII | 438 |
CCLXV | 439 |
CCLXVII | 440 |
CCLXIX | 441 |
CCLXXI | 442 |
CCLXXII | 443 |
CCLXXIII | 455 |
CCLXXVI | 456 |
CCLXXVII | 457 |
CCLXXVIII | 458 |
CCLXXIX | 459 |
CCLXXXI | 460 |
CCLXXXII | 461 |
CCLXXXIII | 462 |
CCLXXXV | 464 |
CCLXXXVI | 465 |
CCLXXXVII | 467 |
CCLXXXVIII | 469 |
CCXCI | 470 |
CCXCIV | 477 |
CCXCVI | 478 |
CCXCVII | 481 |
CCXCVIII | 483 |
CCXCIX | 487 |
CCC | 490 |
CCCII | 497 |
CCCIV | 498 |
CCCV | 504 |
CCCVI | 506 |
CCCVII | 507 |
CCCVIII | 508 |
CCCIX | 509 |
CCCX | 511 |
CCCXI | 512 |
CCCXII | 513 |
CCCXIII | 515 |
CCCXIV | 516 |
CCCXV | 525 |
CCCXVIII | 526 |
CCCXIX | 530 |
CCCXX | 533 |
CCCXXI | 534 |
CCCXXII | 535 |
CCCXXIII | 539 |
CCCXXV | 540 |
CCCXXVII | 541 |
CCCXXVIII | 545 |
CCCXXIX | 549 |
CCCXXXI | 550 |
CCCXXXII | 551 |
CCCXXXIII | 552 |
CCCXXXIV | 553 |
CCCXXXV | 554 |
CCCXXXVI | 555 |
CCCXXXVII | 563 |
CCCXL | 564 |
CCCXLI | 566 |
CCCXLII | 567 |
CCCXLIII | 568 |
CCCXLIV | 569 |
CCCXLV | 570 |
CCCXLVI | 571 |
CCCXLVII | 572 |
CCCXLIX | 574 |
CCCLI | 575 |
CCCLII | 576 |
CCCLIV | 577 |
CCCLV | 579 |
CCCLVII | 587 |
CCCLX | 588 |
CCCLXI | 589 |
CCCLXII | 592 |
CCCLXIII | 593 |
CCCLXIV | 594 |
CCCLXVIII | 595 |
CCCLXIX | 603 |
CCCLXXII | 606 |
CCCLXXIII | 607 |
CCCLXXV | 610 |
CCCLXXVI | 611 |
CCCLXXVII | 614 |
CCCLXXVIII | 616 |
CCCLXXIX | 617 |
CCCLXXX | 618 |
CCCLXXXII | 619 |
CCCLXXXIII | 621 |
CCCLXXXIV | 622 |
CCCLXXXVI | 623 |
CCCLXXXVII | 624 |
CCCLXXXVIII | 625 |
CCCXC | 626 |
CCCXCI | 632 |
CCCXCII | 636 |
CCCXCIII | 639 |
CCCXCV | 640 |
CCCXCVI | 643 |
CCCXCVII | 644 |
CCCXCVIII | 645 |
CCCXCIX | 646 |
CD | 648 |
CDI | 649 |
CDII | 650 |
CDIII | 654 |
CDIV | 656 |
CDV | 659 |
CDVI | 660 |
CDVII | 661 |
CDVIII | 662 |
CDIX | 663 |
CDX | 664 |
CDXI | 665 |
CDXII | 667 |
CDXIV | 668 |
CDXV | 670 |
CDXVI | 672 |
CDXVIII | 673 |
CDXIX | 676 |
CDXX | 678 |
CDXXI | 680 |
CDXXII | 681 |
CDXXIII | 682 |
CDXXIV | 684 |
CDXXV | 688 |
CDXXVI | 689 |
CDXXVII | 690 |
CDXXVIII | 691 |
CDXXIX | 692 |
CDXXX | 693 |
CDXXXI | 698 |
CDXXXII | 701 |
CDXXXIII | 704 |
CDXXXIV | 706 |
CDXXXVI | 708 |
CDXXXVIII | 710 |
CDXXXIX | 715 |
CDXL | 751 |
CDXLIV | 752 |
CDXLV | 753 |
CDXLVI | 754 |
CDL | 755 |
CDLI | 757 |
CDLII | 758 |
CDLIII | 760 |
CDLIV | 761 |
CDLV | 762 |
CDLVI | 763 |
CDLVII | 764 |
CDLVIII | 765 |
CDLX | 766 |
CDLXI | 767 |
CDLXII | 779 |
CDLXIV | 781 |
CDLXV | 782 |
CDLXVI | 783 |
CDLXVII | 785 |
CDLXVIII | 786 |
CDLXIX | 787 |
CDLXXI | 788 |
CDLXXII | 790 |
CDLXXIII | 791 |
CDLXXIV | 793 |
CDLXXV | 795 |
CDLXXVI | 796 |
CDLXXVII | 798 |
CDLXXVIII | 799 |
CDLXXIX | 800 |
CDLXXX | 802 |
CDLXXXII | 803 |
CDLXXXIV | 804 |
813 | |
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Common terms and phrases
3H]nicotine a-Bgt a-bungarotoxin a-conotoxin a7 nAChRs a7 subunit AChRs activity agonist ALKONDON Alzheimer's disease antagonists Ballivet behavior Berg DK Bertrand binding sites Biol Chem blocked Brain Res bungarotoxin Ca2+ calcium Changeux JP choline receptor cholinergic chronic nicotine ciliary ganglion cognitive cortex cytisine desensitization dopamine doses drug effects of nicotine epibatidine expression functional ganglia high affinity hippocampal human increase inhibition interneurons ion channel ligand Lindstrom mecamylamine membrane mg/kg mice modulation mouse mRNA muscle mutation nAChR subtypes nAChR subunit nervous system Neurochem neuronal nAChRs neuronal nicotinic acetylcholine neuronal nicotinic receptors Neurosci nico nicotine-induced nicotinic acetylcholine receptor nicotinic agonists nicotinic receptors Nordberg nucleus nucleus accumbens oocytes Parkinson's disease Pharmacol Biochem Behav Pharmacol Exp Ther pharmacological Physiol presynaptic properties protein Psychopharmacology rapsyn rat brain recep receptor subunit region release response role self-administration sensitivity sequence smoking stimulation studies subunit synaptosomes tinic tion tolerance toxin transcription vivo Wonnacott Xenopus oocytes
References to this book
Ion Channels: From Atomic Resolution Physiology to Functional Genomics Novartis Foundation No preview available - 2002 |