Transdermal Fentanyl: A New Approach to Prolonged Pain ControlKlaus A. Lehmann, Detlev Zech That pain is a serious clinical problem, which requires considerable effortsby physicians and the nursing staff, has been stressed in numerous publications. Transdermal application is well known for a variety of drugs, including cardiovascular drugs, antiemetics and hormones. Some years ago, first experience was also made with transdermally administered opiates from which the transdermal therapeutic system (TTS) fentanyl has now been approved by the American Food and Drug Administration. The book presents the results of the first international workshop "Transdermal Fentanyl", held September 27 -28, 1990 in Cologne, FRG. This workshop was intended to facilitate a critical evaluation of theoretical and clinical studies with the new, non-invasive fentanyl application and to provide an opportunity for an exchange of ideas about its value for pain management, anaesthesiology and future investigations in this field. Topics covered by the book are physiology of transdermal permeation, experience with other transdermal systems, the present state of acute and chronic pain management and experimental and clinical studies with transdermal fentanyl, with special concern to analgesic efficacy and side effects. Readers will easily find out that the experts appreciated transdermal analgesia but also warned against an uncritical optimism. TTS fentanyl can be a valuable tool in the clinicians' armentarium against pain. It should be kept in mind, however, that it represents a new administration mode, not a new drug, and that the sustained, non-invasive application requires well reflected diagnosis and good general standards of pain management. |
Contents
Clinical Efficacy Experience in Clinical Practice with Cancer Patients | |
Glyceryl Trinitrate Nitroglycerin 2 5 5 10 or 15 mg over 24 | |
Conclusion | |
Methods | |
Conclusions | |
Cancer Pain | |
Discussion | |
References | |
New Developments | |
Pharmacokinetics and Pharmacodynamics | |
Summary | |
References | |
Patients and Methods | |
Clinical Experience | |
Discussion | |
Other editions - View all
Transdermal Fentanyl: A New Approach to Prolonged Pain Control Klaus A. Lehmann,Detlev Zech No preview available - 1991 |
Common terms and phrases
abdominal absorption Acta Anaesthesiol administration alfentanil Alza Corporation Anaesth analgesia analgesic Anesth Analg anesthesia Anesthesiology antipyretic assessment blood concentration blood fentanyl concentrations bupivacaine buprenorphine cancer cancer pain cancer patients chronic clearance Clin clinical trials clonidine Diclofenac disease dosage double blind drug concentrations drug delivery epidural evaluation fentanyl pharmacokinetics functioning halflife infusion inthe intravenous Lehmann measures metabolism morphine multidimensional narcotic nausea ng/ml Nimmo WS nitroglycerin ofdrug offentanyl ofpain ofpatients ofthe onthe opiate opioid OTFC pain control pain intensity pain management pain reduction pain relief pain research paracetamol Patientcontrolled analgesia patientswith pethidine pharmacokinetics pharmacokinetics and pharmacodynamics pharmacokinetics of fentanyl Pharmacol placebo placebo group postoperative analgesia postoperative pain premedication problem receptor reported respiratory depression scopolamine scores sedation serum skin sufentanil surgery surgical symptoms tissue tothe transdermal delivery Transdermal fentanyl transdermal system Transdermal Therapeutic Systems transmucosal fentanyl citrate treatment TTS fentanyl systems wellbeing µg/h