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addition amount angle appears applied approximately band becomes calculated Chem coefficient compared complex concentration conformation constant containing contribution corresponding creatine density dependence derived described determined diffusible components dilute discussed effect electron enzyme equation equilibrium estimate et al example experimental experiments expression factor field function given gives grams gyration increase indicated intensity interaction known length magnetic mass measurements medium membrane method mole molecular weight molecule negative observed obtained optical activity parameter partial plot positive possible pressure procedure protein solution pulse quantity radius range ratio reference region relative residues respectively rotational strength sample scattering curve shape shown side similar solvent specific volume spectra spectrum sphere standard structure studies Table techniques temperature theoretical theory tion transition usually various vary wavelength weight X-ray zero