Molecular Design and Modeling: Concepts and Applications. Part A, Proteins, Peptides, and EnzymesJohn Joseph Langone Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs. |
Contents
Predicting Protein Secondary Structure Based on KEN NISHIKAWA | 3 |
Comparative Modeling of Homologous Proteins JONATHAN GREER 239 | 13 |
Enzymatic Catalysis on Organic Synthesis C H WONG G J SHEN | 26 |
Amino Acid Sequence TAMOTSU NOGUCHI | 31 |
Use of Homologous Sequences to Improve Pro THOMAS NIERMANN | 45 |
BANCINYANE LYNN SIBANDA | 59 |
Protein Engineering in Analysis of Protein Folding ANDREAS MATOUSCHEK | 82 |
Mutational Analysis of Protein Folding Mecha PATRICIA A JENNINGS | 113 |
Aspects of the Design of Conformationally Con PAUL E SMITH | 411 |
Design of Minimum Active Fragments of Biologi WILLIAM M BRYAN | 436 |
Molecular Modeling and Dynamics of Biologically ALEXANDER D MACKERELL | 449 |
DiffusionControlled Enzymatic Reactions MALCOLM E Davis | 473 |
Theoretical Calculations of Relative Affinities of T P STRAATSMA | 497 |
Quantitative StructureActivity Relationships and CORWIN HANSCH | 512 |
Modification of Enzyme Catalysis by Engineering GREGORIO ALVARO | 620 |
Mutational Remodeling of Enzyme Specificity ROGER BONE | 643 |
Clefts and Binding Sites in Protein Receptors RICHARD A Lewis | 126 |
Modeling of Side Chains Loops and Insertions in NEENA L SUMMERS | 156 |
Neural Networks for Protein Structure Prediction L Howard Holley | 204 |
Prediction of a Helices and T CellPresented Se VICTOR E REYES | 225 |
Combined Procedures of Distance Geometry and JACOB DE VLIEG | 268 |
Biosynthetic Method for Introducing Unnatural JON ELLMAN DAvid Mendel | 301 |
Stabilization of Functional Proteins by Introduc MASAZUMI MATSUMURA | 336 |
Complete Mutagenesis of Protein Coding Domains CLYDE A HUTCHISON III | 356 |
Systematic Mutational Analyses of ProteinPro JAMES A WELLS | 390 |
Modulation of Enzyme Specificity by SiteDi LIZBETH HEDSTROM | 671 |
Analysis of StructureFunction Relationships by MELINDA E WALES | 687 |
Generation of Allosteric Enzymes from Nonallo LAWRENCE C KUO | 706 |
Modeling of Structure of Human Immunodefi IRENE T WEBER | 727 |
Modulation of Specificity and Activity in Mamma RAIJA L P LINDBERG | 741 |
Previously Published Articles from Methods in | 755 |
AUTHOR INDEX | 761 |
| 799 | |
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Molecular Design and Modeling: Concepts and Applications, Part A ..., Volume 202 No preview available - 1991 |
Common terms and phrases
Acad accessible algorithm aligned amino acid analysis atoms average backbone barnase binding sites Biochemistry Biol Biophys Biopolymers calculated changes Chem clefts coil correlation database deletions denaturant determined dihedral angles distance disulfide bonds domains electrostatic enzyme experimental folding pathway fragment free energy function groups helices helix homologous hydrogen bond input interaction energy intermediate Karplus kcal/mol kinetic known structures ligand loop lysozyme minimization molecular dynamics molecule mutations Natl Nature London neural network observed obtained output parameters pattern peptide positions potential energy prediction accuracy prediction methods probe sphere Proc procedure profiles propensity protease protein folding protein structure proteinase rate constant reaction reaction coordinate receptor refolding regions residue pairs secondary structure segment side chains side-chain conformations simulations solvent ẞ hairpins ẞ strands stability statistical structure prediction Table template tertiary structure tion transition tRNA unfolded form urea VOLUME Waals wild-type