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abnormalities acute hepatitis acute viral hepatitis agent albumin alcoholic hepatitis alcoholic liver disease amino acids antibody antigen ascites associated atitis Berk PD bile acids bile duct bilirubin Biochem bleeding blood ﬂow cause cholangitis cholestasis cholestatic cholesterol chronic active hepatitis chronic hepatitis chronic liver disease cirrhotic clinical collagen concentration conjugated cytoplasm develop diagnosis drug effect encephalopathy Engl enzyme excretion fatty liver fibrosis ﬂuid function Gastroenterol Gastroenterology Gilbert's syndrome HBsAg heme hepa hepatocellular hepatocytes Hepatology histologic hyperbilirubinemia increased infection inﬂammatory intrahepatic jaundice Lancet lesion levels Lieber lipid liver biopsy liver cell liver injury lymphocytes membrane microsomal necrosis non-A non-B hepatitis normal oxidation pathogenesis Pathol patients plasma Popper H portal hypertension portal tracts primary biliary cirrhosis protein rat liver renal reported Schaffner F Sherlock shunt sinusoidal sodium studies synthesis therapy tients tion tissue toxic transferase treatment unconjugated uptake usually varices vein viral hepatitis